Lion's Mane Mushroom для Mild Cognitive Impairment (MCI)

Q: Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

Q: How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.

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Итог

Key Study Findings

Review

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …

Dose: None или: None Outcome: Schizophrenia symptom improvement (theoretical) Эффект: None None

Популяция: Patients with chronic/treatment-resistant schizophrenia

Review

ALSUntangled #73: Lion's Mane.

Dose: Hericium erinaceus (Lion's Mane) или: None Outcome: Neuroprotection and ALS progression Эффект: None None

Популяция: ALS patients (limited evidence)

Review

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …

Dose: Hericium erinaceus (Lion's Mane) extracts или: None Outcome: Neuroprotection and cognitive improvement Эффект: None None

Популяция: Neurodegenerative disease patients (review)

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

In Vitro

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

Dose: erinacine A-enriched H. erinaceus mycelium (300mg/kg) или: untreated transgenic mice Outcome: AD pathology markers and neurogenesis Эффект: reduced amyloid plaque, increased neurogenesis <0.05

Популяция: APPswe/PS1dE9 transgenic AD mice

Randomized Controlled Trial n=30 2.0 weeks Double-blind

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled …

Dose: 250 mg или: placebo Outcome: cognitive function Эффект: None None

Популяция: dementia patients

Key Statistics

Исследования

400

Участники

↑

Positive

Оценка

Referenced Papers

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. Review

Psychopharmacology bulletin 2025

ALSUntangled #73: Lion's Mane. Other

Amyotrophic lateral sclerosis … 2024 2 цитирований

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Review

Journal of fungi … 2023 44 цитирований

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 цитирований

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. Other

Journal of biomedical … 2016 98 цитирований

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. RCT

Phytotherapy research : … 2009 227 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 500-3,000 mg/day
cognitivesupport:: 1,000-3,000 mg/day of fruiting body extract

Верхний предел: Not established; well-tolerated up to 3,000 mg/day

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Positive	--
Hericium erinaceus (Lion's Mane)	--	Neutral	--
Hericium erinaceus (Lion's Mane) extracts	--	Positive	--
None	--	Mixed	--
erinacine A-enriched H. erinaceus mycelium (300mg/kg)	--	Positive	--
250 mg	2.0 weeks	Positive	30

Лучшее время приёма: With meals; effects observed after 8-16 weeks of consistent use

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Mild gastrointestinal discomfort
⚠ Skin rash in rare cases (especially with allergies to mushrooms)
⚠ Potential itching or tingling sensations

Известные взаимодействия

● Anticoagulants (may have mild antiplatelet effects)
● Antidiabetic medications (may lower blood sugar)
● Immunosuppressants (may modulate immune function)

Допустимый верхний уровень потребления: Not established; well-tolerated up to 3,000 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Mild Cognitive Impairment (MCI)

Omega-3 Fatty Acids (DHA/EPA) B

Lion's Mane Mushroom для других состояний

Memory Loss C Brain Fog C

Краткий вывод

Evidence Strength72%

High confidence

Разбор исследований

RCT (1)Meta (0)Other (5)

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Узнайте, как другие ингредиенты сравниваются при данном состоянии.

Посмотреть все ингредиенты для Mild Cognitive Impairment (MCI)

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