N-Acetyl Cysteine для Depression-Related Cognitive Dysfunction

Research suggests NAC's glutamate modulation and glutathione restoration may help address cognitive aspects of depression. Evidence is emerging from several clinical studies exploring NAC as an adjunctive treatment.

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Итог

Key Study Findings

Review

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.

Dose: None или: None Outcome: None Эффект: None None

Популяция: restless legs syndrome

Review

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Other n=24 2 weeks

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.

Dose: NAC 100 mg/kg body weight orally daily for 14 days или: Placebo Эффект: significant augmentation of antioxidants and reduction of prooxidants in old rats; downregulation of None

Review

Restless legs syndrome.

Dose: None или: None Outcome: quality of life Эффект: None None

Популяция: cardiovascular patients

In Vitro

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.

Dose: Valerian extract and valerenic acid или: LSD binding Outcome: 5-HT5a receptor binding affinity Эффект: PE extract IC50 15.7 ng/ml (high affinity) None

Популяция: None

Key Statistics

Исследования

400

Участники

↑

Positive

Оценка

Referenced Papers

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. Review

Sleep medicine clinics 2021 14 цитирований

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? Review

Neuroscience and biobehavioral … 2019 45 цитирований

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 цитирований

Restless legs syndrome. Review

Handbook of clinical … 2011 8 цитирований

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Other

Brain research. Molecular … 2005 160 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 600-1,800 mg/day
neuroprotection:: 1,200-2,400 mg/day

Верхний предел: Not established as supplement; 6,000+ mg/day used clinically (IV)

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Mixed	--
None	--	Positive	--
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--
Valerian extract and valerenic acid	--	Positive	--

Лучшее время приёма: On empty stomach; split into 2-3 doses; supplement zinc if using long-term

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Nausea and vomiting
⚠ Diarrhea
⚠ Unpleasant sulfur taste/smell
⚠ Rare: bronchospasm (inhaled form)
⚠ Long-term use may deplete zinc stores

Известные взаимодействия

● Nitroglycerin (may enhance hypotensive effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical interaction)

Допустимый верхний уровень потребления: Not established as supplement; 6,000+ mg/day used clinically (IV)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does N-Acetyl Cysteine help with Depression-Related Cognitive Dysfunction?

Based on 6 studies with 400 participants, there is limited but promising evidence that N-Acetyl Cysteine may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).

How much N-Acetyl Cysteine should I take for Depression-Related Cognitive Dysfunction?

Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine?

Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine and Depression-Related Cognitive Dysfunction?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Depression-Related Cognitive Dysfunction

Omega-3 Fatty Acids (DHA/EPA) B Vitamin D C

N-Acetyl Cysteine для других состояний

Oxidative Stress & Neuroinflammation B Post-Concussion Cognitive Symptoms B

Краткий вывод

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (0)Meta (0)Other (6)

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Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.