Acetyl-L-Carnitine 用于 Age-Related Cognitive Decline

Mixed results in healthy adults but more consistently positive outcomes in elderly populations with existing cognitive concerns. Used as a prescription drug in some European countries for cognitive impairment.

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结论

Key Study Findings

Randomized Controlled Trial

Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized …

Dose: None vs: None Outcome: Cognitive decline 效果: None None

研究人群: Alzheimer's disease patients

Systematic Review

Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Review

Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Chronic pain patients (preclinical review)

Review

Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy …

Dose: None vs: None Outcome: None 效果: None None

研究人群: Parkinson's disease patients

Controlled Clinical Trial

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.

Dose: mitochondrial cofactors + antioxidants vs: control diet Outcome: cognitive function in aged dogs 效果: improved learning and memory None

研究人群: Aged beagle dogs

Randomized Controlled Trial n=106 Double-blind

A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in …

Dose: None vs: placebo Outcome: None 效果: None p = 0.0083

研究人群: Alzheimer's disease patients

Key Statistics

研究数量

1000

受试者

↑

Positive

等级

Referenced Papers

Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial. RCT

Medicine 2024 3 次引用

Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update. Review

Nutrients 2020 72 次引用

Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management. Review

Ageing research reviews 2017 56 次引用

Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies. Other

Journal of pain … 2017 49 次引用

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Other

Neurobiology of aging 2016 19 次引用

A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease. RCT

Journal of Alzheimer's … 2015 112 次引用

Pharmacological interventions for cognitive decline in people with Down syndrome. Meta-Analysis

The Cochrane database … 2015 33 次引用

n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Other

Frontiers in aging … 2014 111 次引用

A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. RCT

The journal of … 2010 70 次引用

Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … Other

Nutrition research (New … 2009 65 次引用

Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Review

Alternative medicine review … 2008

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. Other

FASEB journal : … 2007 52 次引用

Acetyl-L-carnitine for dementia. Systematic Review

The Cochrane database … 2003 94 次引用

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 次引用

[Methodology of a clinical controlled study of L-acetylcarnitine]. CCT

La Clinica terapeutica 1990 3 次引用

Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome. RCT

International journal of … 1990

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 500-2,000 mg/day
cognitivesupport:: 1,500-3,000 mg/day

上限： Well-tolerated up to 3,000 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
mitochondrial cofactors + antioxidants	--	Positive	--
None	--	Positive	106
None	--	Positive	427
None	8.0 weeks	Positive	--

最佳服用时间： Morning, on empty stomach or with meals

Safety & Side Effects

已报告的副作用

⚠ Gastrointestinal discomfort (nausea, vomiting, diarrhea)
⚠ Fishy body odor
⚠ Restlessness or insomnia
⚠ Increased appetite

已知相互作用

● Anticoagulants (may increase bleeding risk)
● Thyroid medications (may enhance thyroid hormone effects)
● AZT (antiretroviral — may reduce neuropathy)

可耐受最高摄入量： Well-tolerated up to 3,000 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Acetyl-L-Carnitine help with Age-Related Cognitive Decline?

Based on 14 studies with 1,000 participants, there is limited but promising evidence that Acetyl-L-Carnitine may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).

How much Acetyl-L-Carnitine should I take for Age-Related Cognitive Decline?

Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Acetyl-L-Carnitine?

Reported side effects may include Gastrointestinal discomfort (nausea, vomiting, diarrhea), Fishy body odor, Restlessness or insomnia, Increased appetite. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Acetyl-L-Carnitine and Age-Related Cognitive Decline?

We rate the evidence as Grade C (Some Evidence). This rating is based on 14 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Age-Related Cognitive Decline

Omega-3 Fatty Acids (DHA/EPA) A Phosphatidylserine B Bacopa monnieri B Vitamin B12 B Curcumin B Ginkgo biloba C

Acetyl-L-Carnitine 用于其他健康状况

Oxidative Stress & Neuroinflammation C

快速结论

Evidence Strength52%

Moderate confidence

研究分析

RCT (4)Meta (1)Other (9)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Age-Related Cognitive Decline

了解更多

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