Acetyl-L-Carnitine के लिए Age-Related Cognitive Decline
C साक्ष्य की तुलना करें छोटे अध्ययनों से सीमित साक्ष्य उपलब्ध हैं, लेकिन कुछ सकारात्मक संकेत मौजूद हैं।Mixed results in healthy adults but more consistently positive outcomes in elderly populations with existing cognitive concerns. Used as a prescription drug in some European countries for cognitive impairment.
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C
निष्कर्ष
Mixed results in healthy adults but more consistently positive outcomes in elderly populations with existing cognitive concerns. Used as a prescription drug in some European countries for cognitive impairment.
Key Study Findings
Randomized Controlled Trial
Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized …
Dose: None
बनाम: None
Outcome: Cognitive decline
प्रभाव: None
None
जनसंख्या: Alzheimer's disease patients
Systematic Review
Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update.
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: None
Review
Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies.
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: Chronic pain patients (preclinical review)
Review
Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy …
Dose: None
बनाम: None
Outcome: None
प्रभाव: None
None
जनसंख्या: Parkinson's disease patients
Controlled Clinical Trial
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Dose: mitochondrial cofactors + antioxidants
बनाम: control diet
Outcome: cognitive function in aged dogs
प्रभाव: improved learning and memory
None
जनसंख्या: Aged beagle dogs
Randomized Controlled Trial
n=106
Double-blind
A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in …
Dose: None
बनाम: placebo
Outcome: None
प्रभाव: None
p = 0.0083
जनसंख्या: Alzheimer's disease patients
Key Statistics
14
अध्ययन
1000
प्रतिभागी
↑
Positive
C
ग्रेड
Referenced Papers
Medicine
2024
3 उद्धरण
Nutrients
2020
72 उद्धरण
Ageing research reviews
2017
56 उद्धरण
Journal of pain …
2017
49 उद्धरण
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Other
Neurobiology of aging
2016
19 उद्धरण
Journal of Alzheimer's …
2015
112 उद्धरण
The Cochrane database …
2015
33 उद्धरण
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice.
Other
Frontiers in aging …
2014
111 उद्धरण
The journal of …
2010
70 उद्धरण
Nutrition research (New …
2009
65 उद्धरण
Alternative medicine review …
2008
FASEB journal : …
2007
52 उद्धरण
Acetyl-L-carnitine for dementia.
Systematic Review
The Cochrane database …
2003
94 उद्धरण
Alternative medicine review …
1999
112 उद्धरण
La Clinica terapeutica
1990
3 उद्धरण
International journal of …
1990
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 500-2,000 mg/day
- cognitivesupport:
- 1,500-3,000 mg/day
अधिकतम सीमा: Well-tolerated up to 3,000 mg/day
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| mitochondrial cofactors + antioxidants | -- | Positive | -- |
| None | -- | Positive | 106 |
| None | -- | Positive | 427 |
| None | 8.0 weeks | Positive | -- |
सेवन का सर्वोत्तम समय: Morning, on empty stomach or with meals
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Gastrointestinal discomfort (nausea, vomiting, diarrhea)
- ⚠ Fishy body odor
- ⚠ Restlessness or insomnia
- ⚠ Increased appetite
ज्ञात अंतःक्रियाएँ
- ● Anticoagulants (may increase bleeding risk)
- ● Thyroid medications (may enhance thyroid hormone effects)
- ● AZT (antiretroviral — may reduce neuropathy)
सहनीय अधिकतम सेवन: Well-tolerated up to 3,000 mg/day
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does Acetyl-L-Carnitine help with Age-Related Cognitive Decline?
Based on 14 studies with 1,000 participants, there is limited but promising evidence that Acetyl-L-Carnitine may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Acetyl-L-Carnitine should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Acetyl-L-Carnitine?
Reported side effects may include Gastrointestinal discomfort (nausea, vomiting, diarrhea), Fishy body odor, Restlessness or insomnia, Increased appetite. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Acetyl-L-Carnitine and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 14 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Age-Related Cognitive Decline
Acetyl-L-Carnitine अन्य स्वास्थ्य स्थितियों के लिए
References
- [1] Wankiun Lee et al.. Medicine (Baltimore). 2024. Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial. doi:10.1097/MD.0000000000038067 PubMed
- [2] Manuela Pennisi et al.. Nutrients. 2020. Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update. doi:10.3390/nu12051389 PubMed
- [3] Oliver T Phillipson. Ageing Res Rev. 2017. Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management. doi:10.1016/j.arr.2017.09.006 PubMed
- [4] Mariagrazia Grilli. J Pain Res. 2017. Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies. doi:10.2147/JPR.S146399 PubMed
- [5] Shikha Snigdha et al.. Neurobiol Aging. 2016. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. doi:10.1016/j.neurobiolaging.2015.09.015 PubMed
- [6] Ruth Remington et al.. J Alzheimers Dis. 2015. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease. doi:10.3233/JAD-142499 PubMed
- [7] Nuala Livingstone et al.. Cochrane Database Syst Rev. 2015. Pharmacological interventions for cognitive decline in people with Down syndrome. doi:10.1002/14651858.CD011546.pub2 PubMed
- [8] Debora Cutuli et al.. Front Aging Neurosci. 2014. n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. doi:10.3389/fnagi.2014.00220 PubMed
- [9] A Chan et al.. J Nutr Health Aging. 2010. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. doi:10.1007/s12603-010-0054-5 PubMed
- [10] James Suchy et al.. Nutr Res. 2009. Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … doi:10.1016/j.nutres.2008.11.004 PubMed
- [11] Parris M Kidd. Altern Med Rev. 2008. Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. PubMed
- [12] N W Milgram et al.. FASEB J. 2007. Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. doi:10.1096/fj.07-8531com PubMed
- [13] S Hudson et al.. Cochrane Database Syst Rev. 2003. Acetyl-L-carnitine for dementia. doi:10.1002/14651858.CD003158 PubMed
- [14] P M Kidd. Altern Med Rev. 1999. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. PubMed
- [15] M Neri et al.. Clin Ter. 1990. [Methodology of a clinical controlled study of L-acetylcarnitine]. PubMed
- [16] W M Herrmann et al.. Int J Clin Pharmacol Res. 1990. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome. PubMed
FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।