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Creatine 用于 Mental Fatigue

B

A systematic review found moderate certainty evidence for positive effects on memory and processing speed. Single-dose supplementation improved cognitive performance during sleep deprivation through ATP replenishment.

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B

结论

A systematic review found moderate certainty evidence for positive effects on memory and processing speed. Single-dose supplementation improved cognitive performance during sleep deprivation through ATP replenishment.

Key Study Findings

Review
Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse?
Dose: None vs: None Outcome: None 效果: None None

研究人群: narrative review of creatine supplementation effects on brain function

Other 24 weeks
Analysis of Incidence and Clinical Characteristics of RSV Infection in Hospitalized Children: A Retrospective Study.
Dose: 71.9% vs: None Outcome: None 效果: None None

研究人群: rsv infection from january 2019 to december 2020

Randomized Controlled Trial Double-blind
Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills?
Dose: 20 g vs: placebo Outcome: throughout the protocol 效果: None P = 0.022

研究人群: healthy participants

Review
Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain …
Dose: 20 g/d vs: Placebo Outcome: None 效果: None None

研究人群: elderly

Cohort Study n=480
Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
Dose: None vs: Control Outcome: Cognitive function 效果: None p=0.05

研究人群: patients with fatigue and 240 controls without fatigue,

Systematic Review n=281
Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized …
Dose: None vs: None Outcome: Cognitive function (memory, intelligence/reasoning) 效果: None None

研究人群: Healthy individuals

Key Statistics

8

研究数量

600

受试者

Positive

B

等级

Referenced Papers

Nutrition (Burbank, Los … 2009 85 次引用
Pharmacology, biochemistry, and … 1998 60 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:
3-5 g/day creatine monohydrate
cognitivesupport:
5 g/day

上限: 5 g/day considered safe for long-term use (ISSN position)

研究中使用的剂量

剂量 持续时间 效果 N
None -- Mixed --
71.9% 24 weeks Positive --
20 g -- Positive --
20 g/d -- Positive --
None -- Mixed 480
None -- Positive 281
None -- Positive 16
None -- Positive --

最佳服用时间: Any time of day; with or without food

Safety & Side Effects

已报告的副作用

  • Water retention
  • Mild gastrointestinal discomfort
  • Weight gain (water weight)
  • Muscle cramping (rare, dose-dependent)

已知相互作用

  • Nephrotoxic drugs (monitor kidney function with concurrent use)
  • Caffeine (may partially attenuate creatine loading, debated)
  • NSAIDs (theoretical additive kidney stress at high doses)

可耐受最高摄入量: 5 g/day considered safe for long-term use (ISSN position)

在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Creatine help with Mental Fatigue?
Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Creatine may support Mental Fatigue management. Our evidence grade is B (Good Evidence).
How much Creatine should I take for Mental Fatigue?
Studies have used various dosages. A commonly studied range is 3-5 g/day creatine monohydrate. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Creatine?
Reported side effects may include Water retention, Mild gastrointestinal discomfort, Weight gain (water weight), Muscle cramping (rare, dose-dependent). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Creatine and Mental Fatigue?
We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Mental Fatigue

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