Lutein & Zeaxanthin 用于 Age-Related Cognitive Decline
CA 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
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C
结论
A 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
Key Study Findings
Cohort Study
n=1550
270 weeks
Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older …
Dose: >=112 mg/day vs <112 mg/day
vs: Low AN intake (<112 mg/day)
Outcome: Incident dementia
效果: HR 1.87 (95% CI 1.26-2.77)
None
研究人群: Community residents without dementia aged >=60 years
In Vitro
Construction and In Vitro Evaluation of Brain-Targeted Lutein Liposomes.
Dose: None
vs: Free lutein
Outcome: BBB permeability and lutein stability
效果: 22.73% BBB permeability at 12h
None
研究人群: In vitro BBB model and stability tests
Review
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)
Observational Study
n=72
Association of Habitual Diet Quality and Nutrient Intake with Cognitive Performance in Community-Dwelling Older Adults: …
Dose: None
vs: None
Outcome: Cognitive performance (CERAD battery)
效果: None
0.007 (fiber), 0.004 (K)
研究人群: Community-dwelling older adults aged 65+
Review
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Observational Study
n=60
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
Dose: None
vs: None
Outcome: Carotenoid moderation of cfPWV-cognition relationship
效果: Beta=0.53, p=0.04 for lutein moderation
0.02
研究人群: Adults, mean age 38.6, 70% female
Key Statistics
8
研究数量
600
受试者
↑
Positive
C
等级
Referenced Papers
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2025
28 次引用
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Nutrients
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4 次引用
Nutricion hospitalaria
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4 次引用
Journal of Alzheimer's …
2024
1 次引用
Nutrition research (New …
2024
1 次引用
Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment.
Review
The Proceedings of …
2023
27 次引用
Nutrients
2023
12 次引用
BMC nutrition
2023
10 次引用
Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2.
Observational
Alzheimer's & dementia …
2023
7 次引用
Clinical nutrition (Edinburgh, …
2022
87 次引用
Journal of Alzheimer's …
2022
4 次引用
The American journal …
2021
70 次引用
Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials.
Meta-Analysis
Molecules (Basel, Switzerland)
2021
26 次引用
Journal of nutritional …
2021
26 次引用
Nutrition research (New …
2021
17 次引用
Nutritional neuroscience
2020
72 次引用
The Journal of …
2020
47 次引用
Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.
RCT
Nutrients
2020
43 次引用
Scientific reports
2019
6 次引用
Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
Observational
Neurology
2018
159 次引用
Journal of the …
2018
76 次引用
Journal of Alzheimer's …
2018
63 次引用
Journal of the …
2018
43 次引用
Nutricion hospitalaria
2018
32 次引用
Pharmacological research
2018
26 次引用
Free radical biology …
2017
37 次引用
Frontiers in aging …
2017
28 次引用
Frontiers in aging …
2016
32 次引用
The British journal …
2015
62 次引用
Zhonghua yu fang …
2015
4 次引用
Neurobiology of aging
2014
98 次引用
Journal of aging …
2013
253 次引用
Nutrition journal
2013
26 次引用
Alzheimer disease and …
2011
52 次引用
Nutritional neuroscience
2008
277 次引用
Journal of Alzheimer's …
2008
104 次引用
Asia Pacific journal …
2002
24 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 10-20 mg lutein + 2-4 mg zeaxanthin/day
- cognitivesupport:
- 12 mg lutein + zeaxanthin/day
上限： Not established; 20 mg/day well-tolerated
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| >=112 mg/day vs <112 mg/day | 270 weeks | Positive | 1550 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 72 |
| None | -- | Mixed | -- |
| None | -- | Positive | 60 |
| None | 156 weeks | Positive | 442 |
| MIND, Mediterranean, DASH, HEI-2015 diets | -- | Positive | -- |
最佳服用时间： With meals containing fat
Safety & Side Effects
已报告的副作用
- ⚠ Generally very well-tolerated
- ⚠ Mild skin yellowing at very high doses (carotenodermia, harmless)
已知相互作用
- ● Orlistat (reduces carotenoid absorption)
- ● Cholesterol-lowering drugs (may reduce absorption)
可耐受最高摄入量： Not established; 20 mg/day well-tolerated
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lutein & Zeaxanthin help with Age-Related Cognitive Decline?
Based on 8 studies with 600 participants, there is limited but promising evidence that Lutein & Zeaxanthin may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Lutein & Zeaxanthin should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 10-20 mg lutein + 2-4 mg zeaxanthin/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lutein & Zeaxanthin?
Reported side effects may include Generally very well-tolerated, Mild skin yellowing at very high doses (carotenodermia, harmless). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lutein & Zeaxanthin and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Age-Related Cognitive Decline
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