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Figure 7. Synthetic scheme for synthesis of cumene-d11 from benzene-d6.
Figure 10. Figure 7. Synthetic scheme for synthesis of cumene-d11 from benzene-d6.

विवरण

Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors.

More Figures from This Paper

Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes.

Figure 4

Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes.

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Mutagenesis or competition binding data supporting the classification of three distinct propofol binding site classes on GABAA receptors.

Figure 5

Mutagenesis or competition binding data supporting the classification of three distinct propofol binding site classes on GABAA receptors.

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Structure-activity relationship analysis of propofol analogs at the different GABAA receptor binding sites, informing anesthetic drug design.

Figure 6

Structure-activity relationship analysis of propofol analogs at the different GABAA receptor binding sites, informing anesthetic drug design.

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Molecular dynamics simulation or computational modeling of propofol interactions with GABAA receptor transmembrane domains.

Figure 7

Molecular dynamics simulation or computational modeling of propofol interactions with GABAA receptor transmembrane domains.

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Comparative analysis of propofol binding site occupancy and functional consequences for GABAA receptor channel gating and anesthetic efficacy.

Figure 8

Comparative analysis of propofol binding site occupancy and functional consequences for GABAA receptor channel gating and anesthetic efficacy.

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Supplementary structural or pharmacological data supporting the three-class model of propofol binding to GABAA receptors.

Figure 9

Supplementary structural or pharmacological data supporting the three-class model of propofol binding to GABAA receptors.

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Figure 10

Diagram
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Source Paper

Three classes of propofol binding sites on GABAA receptors.

The Journal of biological chemistry (2024)

PMID: 39270821

DOI: 10.1016/j.jbc.2024.107778

Cite This Figure

![Figure 10: Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors.](https://pdfs.citedhealth.com/figures/39270821/220.png)

> Source: Zi-Wei Chen et al. "Three classes of propofol binding sites on GABAA receptors.." *The Journal of biological chemistry*, 2024. PMID: [39270821](https://pubmed.ncbi.nlm.nih.gov/39270821/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/39270821/220.png" alt="Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors." />
  <figcaption>Figure 10. Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors.<br>  Source: Zi-Wei Chen et al. "Three classes of propofol binding sites on GABAA receptors.." <em>The Journal of biological chemistry</em>, 2024. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/39270821/">39270821</a></figcaption>
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