Ashwagandha untuk Stress-Induced Cognitive Decline

Q: Does Ashwagandha help with Stress-Induced Cognitive Decline?

Based on 14 studies with 1,200 participants, there is moderate evidence from clinical studies that Ashwagandha may support Stress-Induced Cognitive Decline management. Our evidence grade is B (Good Evidence).

Q: How much Ashwagandha should I take for Stress-Induced Cognitive Decline?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Ashwagandha and Stress-Induced Cognitive Decline?

We rate the evidence as Grade B (Good Evidence). This rating is based on 14 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

The most scientifically supported adaptogen for stress-related cognitive outcomes. A double-blind RCT found 240 mg/day for 60 days significantly reduced anxiety with moderate improvements in attention and executive function.

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Kesimpulan

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs: None Outcome: None Efek: None None

Populasi: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo Efek: None None

animal_study

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …

Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) vs: Placebo Efek: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001); <0.0001

In Vitro

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …

Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) vs: Placebo Efek: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker

Key Statistics

Studi

1200

Peserta

↑

Positive

Peringkat

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 sitasi

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 sitasi

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 sitasi

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 300-600 mg/day of root extract (KSM-66 or Sensoril)
cognitivesupport:: 600 mg/day

Batas atas: Not established; well-tolerated up to 1,250 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)	--	Positive	--
ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)	--	Positive	--

Waktu terbaik diminum: With meals; morning or evening depending on individual response

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Drowsiness
⚠ Gastrointestinal discomfort
⚠ Rare: liver injury (with contaminated or high-dose products)
⚠ Thyroid hormone elevation (may affect thyroid medications)

Interaksi yang Diketahui

● Thyroid medications (may increase thyroid hormone levels)
● Sedative medications (additive CNS depression)
● Immunosuppressants (may stimulate immune activity)
● Diabetes medications (may lower blood sugar)

Asupan atas yang dapat ditoleransi: Not established; well-tolerated up to 1,250 mg/day

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Frequently Asked Questions

Does Ashwagandha help with Stress-Induced Cognitive Decline?

Based on 14 studies with 1,200 participants, there is moderate evidence from clinical studies that Ashwagandha may support Stress-Induced Cognitive Decline management. Our evidence grade is B (Good Evidence).

How much Ashwagandha should I take for Stress-Induced Cognitive Decline?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Ashwagandha and Stress-Induced Cognitive Decline?

We rate the evidence as Grade B (Good Evidence). This rating is based on 14 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Stress-Induced Cognitive Decline

Rhodiola rosea B Phosphatidylserine C

Ashwagandha untuk kondisi lain

Anxiety-Related Cognitive Impairment B Sleep-Related Cognitive Impairment C

Kesimpulan Singkat

Evidence Strength72%

High confidence

Rincian Studi

RCT (0)Meta (0)Other (14)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Stress-Induced Cognitive Decline

Pelajari Lebih Lanjut

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