What is the recommended dosage for Curcumin?

General: 500-2,000 mg/day of enhanced bioavailability form; Cognitive Support: 90-180 mg/day Theracurmin or equivalent

What are the side effects of Curcumin?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Headache, Skin rash (rare), Yellow staining of teeth with powder forms.

Curcumin is the primary bioactive compound in turmeric (Curcuma longa). It has potent anti-inflammatory and antioxidant properties and has been studied for its potential neuroprotective effects, including supporting brain-derived neurotrophic factor (BDNF) levels and reducing neuroinflammation.

What dosage of Curcumin has been used in brain health studies?

Cognitive studies have used 500 mg to 2,000 mg of curcumin daily. Bioavailability-enhanced formulations (such as those with piperine, phospholipids, or nanoparticle technology) are preferred because standard curcumin is poorly absorbed. Consult your healthcare provider for guidance.

What are the potential side effects of Curcumin?

Curcumin is generally well tolerated but may cause gastrointestinal discomfort, nausea, or diarrhea at high doses. It may interact with blood-thinning medications, diabetes drugs, and iron absorption. People with gallbladder disease should exercise caution. Consult your doctor.

Curcumin

antioxidant

Also known as: Turmeric Extract, Diferuloylmethane, Theracurmin, Longvida, CurQfen

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About

Curcumin is the primary bioactive compound in turmeric with potent anti-neuroinflammatory and neuroprotective properties. Enhanced bioavailability forms cross the blood-brain barrier and may reduce amyloid-beta aggregation. A UCLA 18-month RCT found bioavailable curcumin improved memory test performance and reduced brain amyloid/tau PET signals in non-demented adults.

How It Works

Crosses the blood-brain barrier in enhanced forms; binds to amyloid-beta plaques reducing aggregation; reduces tau phosphorylation; exhibits potent anti-neuroinflammatory effects; stimulates hippocampal neurogenesis via BDNF upregulation.

Evidence For Conditions

Condition	Grade	Studies	Participants
Oxidative Stress & Neuroinflammation	B	15	1200	View →
Age-Related Cognitive Decline	B	10	800	View →
Memory Loss	C	8	600	View →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Headache
Skin rash (rare)
Yellow staining of teeth with powder forms

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Antidiabetic drugs (may enhance blood sugar lowering)
CYP450 substrates (may affect drug metabolism)
Iron supplements (curcumin may chelate iron)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Alpha-Lipoic Acid Astaxanthin Coenzyme Q10 Lutein & Zeaxanthin PQQ (Pyrroloquinoline Quinone)

Quick Facts

Dosage: General: 500-2,000 mg/day of enhanced bioavailability form; Cognitive_Support: 90-180 mg/day Theracurmin or equivalent
Forms: capsule tablet powder liquid
Natural Sources: Turmeric root (Curcuma longa)
Upper Limit: Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
Best Time: With meals containing fat and black pepper (piperine) for absorption

Evidence Summary

Oxidative Stress & Neuroinflammation B

Age-Related Cognitive Decline B

Memory Loss C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.