What is the recommended dosage for Lutein & Zeaxanthin?

General: 10-20 mg lutein + 2-4 mg zeaxanthin/day; Cognitive Support: 12 mg lutein + zeaxanthin/day

What are the side effects of Lutein & Zeaxanthin?

Potential side effects include: Generally very well-tolerated, Mild skin yellowing at very high doses (carotenodermia, harmless).

What are Lutein and Zeaxanthin?

Lutein and zeaxanthin are carotenoid pigments found in leafy greens, egg yolks, and corn. While primarily known for eye health, these compounds also accumulate in brain tissue. Research suggests they may support cognitive function by reducing oxidative stress and inflammation in the brain.

What dosage of Lutein and Zeaxanthin has been used in cognitive studies?

Cognitive studies have used 10 mg to 20 mg of lutein and 2 mg to 4 mg of zeaxanthin daily. The AREDS2 formulation used 10 mg lutein and 2 mg zeaxanthin. Benefits in cognitive studies were typically observed after 6 to 12 months. Consult your healthcare provider.

What are the potential side effects of Lutein and Zeaxanthin?

Lutein and zeaxanthin supplements are generally well tolerated with few reported side effects. Very high doses may cause harmless yellowing of the skin (carotenodermia). They are fat-soluble and best absorbed with dietary fat. Consult your healthcare provider before supplementing.

Lutein & Zeaxanthin

antioxidant

Also known as: Macular Xanthophylls, Meso-Zeaxanthin, FloraGLO Lutein

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About

Lutein and zeaxanthin are carotenoid antioxidants that accumulate in neural tissue and increase BDNF levels. A 6-month RCT showed they improved composite memory, psychomotor speed, and sustained attention.

How It Works

Carotenoid antioxidants accumulating in neural tissue; increase BDNF levels; reduce pro-inflammatory IL-1beta; protect neuronal membranes from oxidative damage.

Evidence For Conditions

Condition	Grade	Studies	Participants
Age-Related Cognitive Decline	C	8	600	View →

Side Effects

Generally very well-tolerated
Mild skin yellowing at very high doses (carotenodermia, harmless)

Drug & Supplement Interactions

Orlistat (reduces carotenoid absorption)
Cholesterol-lowering drugs (may reduce absorption)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Alpha-Lipoic Acid Astaxanthin Coenzyme Q10 Curcumin PQQ (Pyrroloquinoline Quinone)

Quick Facts

Dosage: General: 10-20 mg lutein + 2-4 mg zeaxanthin/day; Cognitive_Support: 12 mg lutein + zeaxanthin/day
Forms: softgel capsule
Natural Sources: Kale, Spinach, Corn, Egg yolks, Orange peppers
Upper Limit: Not established; 20 mg/day well-tolerated
Best Time: With meals containing fat

Evidence Summary

Age-Related Cognitive Decline C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.