What is the recommended dosage for PQQ (Pyrroloquinoline Quinone)?

General: 10-20 mg/day; Cognitive Support: 20 mg/day

What are the side effects of PQQ (Pyrroloquinoline Quinone)?

Potential side effects include: Headache, Insomnia, Mild fatigue.

Pyrroloquinoline quinone (PQQ) is a redox cofactor found in small amounts in foods like kiwi, parsley, and natto. Research suggests PQQ may support mitochondrial biogenesis (the creation of new mitochondria) and protect neurons from oxidative damage, potentially supporting cognitive function.

What dosage of PQQ has been used in studies?

Human studies have used 10 mg to 20 mg of PQQ daily. Some research has combined PQQ with CoQ10 for potential synergistic effects on mitochondrial function. The evidence base for PQQ and cognition is still emerging. Consult your healthcare provider for dosing guidance.

What are the potential side effects of PQQ?

PQQ appears to be well tolerated at recommended doses in limited human studies. Mild side effects may include headache and fatigue. Long-term safety data is limited. Consult your healthcare provider before supplementing, especially if you are pregnant, nursing, or taking medications.

PQQ (Pyrroloquinoline Quinone)

antioxidant

Also known as: Pyrroloquinoline Quinone, BioPQQ

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About

PQQ promotes mitochondrial biogenesis and is the only known dietary compound to do so. A double-blind trial found 21.5 mg/day improved memory, attention, and cognitive function in middle-aged to elderly populations after 12 weeks.

How It Works

Promotes mitochondrial biogenesis via PGC-1alpha activation; protects neurons from oxidative damage with potency 5,000x greater than vitamin C per molecule; supports nerve growth factor expression.

Evidence For Conditions

Condition	Grade	Studies	Participants
Age-Related Cognitive Decline	C	4	200	View →

Side Effects

Headache
Insomnia
Mild fatigue

Drug & Supplement Interactions

No significant drug interactions established

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Alpha-Lipoic Acid Astaxanthin Coenzyme Q10 Curcumin Lutein & Zeaxanthin

Quick Facts

Dosage: General: 10-20 mg/day; Cognitive_Support: 20 mg/day
Forms: capsule tablet
Natural Sources: Natto, Green peppers, Kiwi, Parsley, Green tea
Upper Limit: Not established; well-tolerated up to 60 mg/day
Best Time: With meals

Evidence Summary

Age-Related Cognitive Decline C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.