What is the recommended dosage for Zinc?

General: 8-11 mg/day (RDA); Cognitive Support: 15-30 mg/day

What are the side effects of Zinc?

Potential side effects include: Nausea on empty stomach, Copper deficiency at chronic high doses, Metallic taste, Headache.

Zinc is an essential trace mineral involved in over 300 enzymatic reactions and plays a critical role in neurotransmission, synaptic plasticity, and neurogenesis. The brain contains high concentrations of zinc, particularly in the hippocampus. Zinc deficiency has been associated with impaired cognitive function.

What dosage of Zinc has been used in cognitive studies?

Cognitive studies have used 15 mg to 30 mg of elemental zinc daily. Zinc picolinate, zinc citrate, and zinc gluconate are well-absorbed forms. The RDA is 8 to 11 mg for adults, and the tolerable upper intake is 40 mg per day. Long-term high-dose zinc may deplete copper. Consult your doctor.

What are the potential side effects of Zinc?

Excessive zinc intake may cause nausea, vomiting, abdominal cramps, and diarrhea. Chronic high-dose supplementation can interfere with copper absorption, leading to copper deficiency anemia. Zinc may interact with antibiotics and diuretics. Consult your healthcare provider for appropriate dosing.

Zinc

mineral

Also known as: Zinc Picolinate, Zinc Glycinate, Zinc Citrate, Zinc Gluconate

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About

Zinc is an essential cofactor for over 300 enzymes involved in neurotransmitter synthesis. It modulates NMDA and GABA receptors and is critical for synaptic plasticity, hippocampal neurogenesis, and long-term potentiation.

How It Works

Essential cofactor for 300+ enzymes in neurotransmitter synthesis; modulates NMDA and GABA receptors; critical for synaptic plasticity, neurogenesis, and BDNF signaling.

Evidence For Conditions

Condition	Grade	Studies	Participants
Neurotransmitter Imbalance	C	8	600	View →

Side Effects

Nausea on empty stomach
Copper deficiency at chronic high doses
Metallic taste
Headache

Drug & Supplement Interactions

Antibiotics (quinolones, tetracyclines — reduced absorption)
Penicillamine (reduced absorption of both)
Iron supplements (competitive absorption)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Magnesium L-Threonate Selenium

Quick Facts

Dosage: General: 8-11 mg/day (RDA); Cognitive_Support: 15-30 mg/day
Forms: capsule tablet lozenge liquid
Natural Sources: Oysters, Red meat, Poultry, Beans, Nuts, Pumpkin seeds
Upper Limit: 40 mg/day (GI effects, copper depletion above)
Best Time: With meals to reduce GI effects; separate from iron by 2 hours

Evidence Summary

Neurotransmitter Imbalance C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.