Rhodiola rosea per Mental Fatigue

Q: Does Rhodiola rosea help with Mental Fatigue?

Based on 11 studies with 900 participants, there is moderate evidence from clinical studies that Rhodiola rosea may support Mental Fatigue management. Our evidence grade is B (Good Evidence).

Q: How much Rhodiola rosea should I take for Mental Fatigue?

Studies have used various dosages. A commonly studied range is 200-600 mg/day standardized to 3% rosavins and 1% salidroside. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Rhodiola rosea?

Reported side effects may include Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Rhodiola rosea and Mental Fatigue?

We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.

Multiple RCTs demonstrate significant reduction in mental fatigue and improved concentration during stressful periods. Rosavin and salidroside appear to be the primary active compounds supporting cognitive endurance.

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Key Study Findings

Randomized Controlled Trial n=18 Double-blind

The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises …

Dose: 4 days supplementation vs: Placebo Outcome: Strength performance in bench-press and bench-pull Effetto: 17 small ESs observed, 14 favoring RR None

Popolazione: Young healthy individuals (7 women, 11 men)

Review

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on …

Dose: None vs: None Outcome: Inflammatory markers Effetto: None None

Popolazione: Depression patients

Randomized Controlled Trial 4.3 weeks Single-blind

Assessing brain function in stressed healthy individuals following the use of a combination of green …

Dose: None vs: placebo Outcome: Brain response to stress and quality of life Effetto: None p = 0.001

Popolazione: Chronically stressed but healthy subjects

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Other 4 weeks

Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance …

Dose: None vs: Control group Outcome: acute and chronic effects of resistance exercise coupled … Effetto: None p < 0.05

Popolazione: None

Review

Adaptogens in mental and behavioral disorders.

Dose: None vs: None Outcome: Stress-protective and stimulative effects Effetto: None None

Popolazione: Adults with mental and behavioral disorders

Key Statistics

Studi

900

Partecipanti

↑

Positive

Grado

Referenced Papers

The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue … RCT

Nutrients 2025 6 citazioni

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea. Review

Journal of neural … 2024 8 citazioni

Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B … Other

Frontiers in nutrition 2023 3 citazioni

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 citazioni

Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis … Other

Journal of the … 2020 25 citazioni

Adaptogens in mental and behavioral disorders. Review

The Psychiatric clinics … 2013 64 citazioni

Rhodiola rosea for physical and mental fatigue: a systematic review. Systematic Review

BMC complementary and … 2012 114 citazioni

Does Rhodiola rosea possess ergogenic properties? Review

International journal of … 2006 40 citazioni

[Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]. Review

Medicina (Kaunas, Lithuania) 2004

A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for … RCT

Phytomedicine : international … 2003 205 citazioni

Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen … RCT

Phytomedicine : international … 2000 281 citazioni

A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of … RCT

Phytomedicine : international … 2000 251 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 200-600 mg/day standardized to 3% rosavins and 1% salidroside

Limite massimo: Not established; doses up to 680 mg/day used in trials

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
4 days supplementation	--	Positive	18
None	--	Mixed	--
None	4.3 weeks	Positive	--
None	--	Mixed	--
None	4 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--

Momento migliore per l'assunzione: Morning on empty stomach; avoid evening (may be stimulating)

Safety & Side Effects

Effetti collaterali segnalati

⚠ Insomnia or overstimulation (if taken late)
⚠ Dry mouth
⚠ Dizziness
⚠ Mild agitation

Interazioni note

● Antidepressants (SSRIs, MAOIs — additive serotonergic effects)
● Antidiabetic drugs (may lower blood sugar)
● Stimulant medications (additive stimulatory effects)
● Immunosuppressants (may modulate immune response)

Livello di assunzione massimo tollerabile: Not established; doses up to 680 mg/day used in trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Rhodiola rosea help with Mental Fatigue?

Based on 11 studies with 900 participants, there is moderate evidence from clinical studies that Rhodiola rosea may support Mental Fatigue management. Our evidence grade is B (Good Evidence).

How much Rhodiola rosea should I take for Mental Fatigue?

Studies have used various dosages. A commonly studied range is 200-600 mg/day standardized to 3% rosavins and 1% salidroside. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Rhodiola rosea?

Reported side effects may include Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Rhodiola rosea and Mental Fatigue?

We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Mental Fatigue

Creatine B Panax Ginseng C

Rhodiola rosea per altre condizioni

Stress-Induced Cognitive Decline B

Verdetto rapido

Evidence Strength72%

High confidence

Analisi degli studi

RCT (4)Meta (0)Other (7)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Mental Fatigue

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.