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Gotu Kola Age-Related Cognitive Decline

D

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

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D

結論

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

Key Study Findings

Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None vs: None Outcome: Cholinesterase inhibition and cognitive improvement 効果: None None

対象集団: In vivo animal models of AD

Controlled Clinical Trial
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep quality and quantity (EEG/EMG) 効果: None None

対象集団: 18-month-old male and female C57BL6/J mice

In Vitro
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …
Dose: None vs: H2O2-induced oxidative stress Outcome: Neuroprotection and cognitive decline biomarkers 効果: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2 None

対象集団: 3D intestinal model and neuronal/astrocytic co-culture

Other
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep composition (REM/NREM duration, arousals) 効果: None None

対象集団: Aged (18-month) C57BL6/J mice

Review
Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.
Dose: None vs: None Outcome: DM and AD symptom management 効果: None None

対象集団: Patients with diabetes and Alzheimer's disease (review)

Other
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Dose: None vs: None Outcome: AChE and BACE1 inhibition for Alzheimer's 効果: None None

対象集団: In silico AD drug discovery (820 metabolites screened)

Key Statistics

4

研究数

200

参加者数

Positive

D

グレード

Referenced Papers

Phytotherapy research : … 2007 256 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:
500-1,000 mg/day standardized extract
cognitivesupport:
750 mg/day

上限量: Not established; hepatotoxicity reported rarely at very high doses

研究で検討された用量

用量 期間 効果 N
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
1 μg/mL -- Positive --

推奨摂取タイミング: With meals

Safety & Side Effects

報告されている副作用

  • Skin irritation (topical)
  • Headache
  • Gastrointestinal discomfort
  • Drowsiness
  • Rare: liver toxicity at very high doses

既知の相互作用

  • Hepatotoxic drugs (additive liver stress)
  • Sedative medications (additive CNS depression)
  • Cholesterol-lowering drugs (theoretical interaction)

耐容上限摂取量: Not established; hepatotoxicity reported rarely at very high doses

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Gotu Kola help with Age-Related Cognitive Decline?
Based on 4 studies with 200 participants, there is preliminary evidence that needs more research that Gotu Kola may support Age-Related Cognitive Decline management. Our evidence grade is D (Very Early Research).
How much Gotu Kola should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Gotu Kola?
Reported side effects may include Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Gotu Kola and Age-Related Cognitive Decline?
We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。