Phosphatidylserine : Age-Related Cognitive Decline
BThe FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
結論
The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
Key Study Findings
対象集団: cerebral FURIN-deficient mice
対象集団: male Sprague-Dawley rats with scopolamine-induced memory impairment
対象集団: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)
対象集団: Alzheimer's disease patients
対象集団: HFD-induced obese male C57BL/6 mice
対象集団: Mouse model
Key Statistics
16
研究数
1100
参加者数
Positive
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 100 mg/day
- cognitivesupport:
- 100-300 mg/day
上限量: Well-tolerated up to 600 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Negative | -- |
| 50, 100, or 200 mg/kg/day | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d | -- | Mixed | -- |
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| 1 μg/mL | -- | Positive | -- |
| None | 72 weeks | Positive | -- |
推奨摂取タイミング: With meals for better absorption
Safety & Side Effects
報告されている副作用
- ⚠ Mild gastrointestinal discomfort
- ⚠ Insomnia at high doses
- ⚠ Rare allergic reactions (soy-derived forms)
既知の相互作用
- ● Anticholinergic medications (may reduce PS effectiveness)
- ● Blood thinners (theoretical interaction)
- ● Cholinesterase inhibitors (additive cholinergic effects)
耐容上限摂取量: Well-tolerated up to 600 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Phosphatidylserine help with Age-Related Cognitive Decline?
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Are there side effects of Phosphatidylserine?
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
Related Evidence
に関する他の成分: Age-Related Cognitive Decline
Phosphatidylserine 他の症状・状態について
FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。