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Phosphatidylserine Age-Related Cognitive Decline

B

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

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B

結論

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

Key Study Findings

Other
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
Dose: None vs: None Outcome: astrocytic lipophagy and cognitive function 効果: None None

対象集団: cerebral FURIN-deficient mice

Other 4 weeks
Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell …
Dose: 50, 100, or 200 mg/kg/day vs: phosphatidylserine 50 mg/kg/day (positive control) Outcome: cognitive performance in scopolamine-induced memory impairment 効果: None None

対象集団: male Sprague-Dawley rats with scopolamine-induced memory impairment

In Vitro
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.
Dose: None vs: None Outcome: Age-dependent brain lipid changes 効果: None None

対象集団: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)

Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d vs: None Outcome: Cognitive decline in AD 効果: None None

対象集団: Alzheimer's disease patients

Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) 効果: None None

対象集団: HFD-induced obese male C57BL/6 mice

Other
Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.
Dose: None vs: None Outcome: Cognitive function 効果: None None

対象集団: Mouse model

Key Statistics

16

研究数

1100

参加者数

Positive

B

グレード

Referenced Papers

The Senior care … 2021 2 件の引用
Nutrition (Burbank, Los … 2015 149 件の引用
Current treatment options … 2011 6 件の引用
Sports medicine (Auckland, … 2006 42 件の引用
Nutritional neuroscience 2002 46 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:
100 mg/day
cognitivesupport:
100-300 mg/day

上限量: Well-tolerated up to 600 mg/day

研究で検討された用量

用量 期間 効果 N
None -- Negative --
50, 100, or 200 mg/kg/day 4 weeks Positive --
None -- Mixed --
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d -- Mixed --
50 mg/kg lycopene in mice -- Positive --
None -- Positive --
1 μg/mL -- Positive --
None 72 weeks Positive --

推奨摂取タイミング: With meals for better absorption

Safety & Side Effects

報告されている副作用

  • Mild gastrointestinal discomfort
  • Insomnia at high doses
  • Rare allergic reactions (soy-derived forms)

既知の相互作用

  • Anticholinergic medications (may reduce PS effectiveness)
  • Blood thinners (theoretical interaction)
  • Cholinesterase inhibitors (additive cholinergic effects)

耐容上限摂取量: Well-tolerated up to 600 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Phosphatidylserine help with Age-Related Cognitive Decline?
Based on 16 studies with 1,100 participants, there is moderate evidence from clinical studies that Phosphatidylserine may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Phosphatidylserine?
Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 1,100 total participants. The overall direction of effect is positive.

Related Evidence

FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。