Rhodiola rosea ： Mental Fatigue

Q: Does Rhodiola rosea help with Mental Fatigue?

Based on 11 studies with 900 participants, there is moderate evidence from clinical studies that Rhodiola rosea may support Mental Fatigue management. Our evidence grade is B (Good Evidence).

Q: How much Rhodiola rosea should I take for Mental Fatigue?

Studies have used various dosages. A commonly studied range is 200-600 mg/day standardized to 3% rosavins and 1% salidroside. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Rhodiola rosea?

Reported side effects may include Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Rhodiola rosea and Mental Fatigue?

We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.

Multiple RCTs demonstrate significant reduction in mental fatigue and improved concentration during stressful periods. Rosavin and salidroside appear to be the primary active compounds supporting cognitive endurance.

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結論

Key Study Findings

Randomized Controlled Trial n=18 Double-blind

The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises …

Dose: 4 days supplementation vs: Placebo Outcome: Strength performance in bench-press and bench-pull 効果: 17 small ESs observed, 14 favoring RR None

対象集団: Young healthy individuals (7 women, 11 men)

Review

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on …

Dose: None vs: None Outcome: Inflammatory markers 効果: None None

対象集団: Depression patients

Randomized Controlled Trial 4.3 weeks Single-blind

Assessing brain function in stressed healthy individuals following the use of a combination of green …

Dose: None vs: placebo Outcome: Brain response to stress and quality of life 効果: None p = 0.001

対象集団: Chronically stressed but healthy subjects

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Other 4 weeks

Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance …

Dose: None vs: Control group Outcome: acute and chronic effects of resistance exercise coupled … 効果: None p < 0.05

対象集団: None

Review

Adaptogens in mental and behavioral disorders.

Dose: None vs: None Outcome: Stress-protective and stimulative effects 効果: None None

対象集団: Adults with mental and behavioral disorders

Key Statistics

研究数

900

参加者数

↑

Positive

グレード

Referenced Papers

The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue … RCT

Nutrients 2025 6 件の引用

Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea. Review

Journal of neural … 2024 8 件の引用

Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B … Other

Frontiers in nutrition 2023 3 件の引用

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 件の引用

Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis … Other

Journal of the … 2020 25 件の引用

Adaptogens in mental and behavioral disorders. Review

The Psychiatric clinics … 2013 64 件の引用

Rhodiola rosea for physical and mental fatigue: a systematic review. Systematic Review

BMC complementary and … 2012 114 件の引用

Does Rhodiola rosea possess ergogenic properties? Review

International journal of … 2006 40 件の引用

[Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine]. Review

Medicina (Kaunas, Lithuania) 2004

A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for … RCT

Phytomedicine : international … 2003 205 件の引用

Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen … RCT

Phytomedicine : international … 2000 281 件の引用

A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of … RCT

Phytomedicine : international … 2000 251 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 200-600 mg/day standardized to 3% rosavins and 1% salidroside

上限量： Not established; doses up to 680 mg/day used in trials

研究で検討された用量

用量	期間	効果	N
4 days supplementation	--	Positive	18
None	--	Mixed	--
None	4.3 weeks	Positive	--
None	--	Mixed	--
None	4 weeks	Mixed	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--

推奨摂取タイミング： Morning on empty stomach; avoid evening (may be stimulating)

Safety & Side Effects

報告されている副作用

⚠ Insomnia or overstimulation (if taken late)
⚠ Dry mouth
⚠ Dizziness
⚠ Mild agitation

既知の相互作用

● Antidepressants (SSRIs, MAOIs — additive serotonergic effects)
● Antidiabetic drugs (may lower blood sugar)
● Stimulant medications (additive stimulatory effects)
● Immunosuppressants (may modulate immune response)

耐容上限摂取量： Not established; doses up to 680 mg/day used in trials

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Rhodiola rosea help with Mental Fatigue?

Based on 11 studies with 900 participants, there is moderate evidence from clinical studies that Rhodiola rosea may support Mental Fatigue management. Our evidence grade is B (Good Evidence).

How much Rhodiola rosea should I take for Mental Fatigue?

Studies have used various dosages. A commonly studied range is 200-600 mg/day standardized to 3% rosavins and 1% salidroside. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Rhodiola rosea?

Reported side effects may include Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Rhodiola rosea and Mental Fatigue?

We rate the evidence as Grade B (Good Evidence). This rating is based on 11 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Mental Fatigue

Creatine B Panax Ginseng C

Rhodiola rosea 他の症状・状態について

Stress-Induced Cognitive Decline B

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (4)Meta (0)Other (7)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Mental Fatigue

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。