Ginkgo biloba 관련 Age-Related Cognitive Decline
CThe most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
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결론
The most studied herbal cognitive supplement. The large GEM trial (3,069 participants) found no evidence for dementia prevention in healthy elderly. However, EGb 761 standardized extract shows modest benefits in existing cognitive impairment.
Key Study Findings
Review
EGb761 Trials for Mild-to-Moderate Dementia-What Have We Learned in the Past 18 years?
Dose: None
vs: placebo
Outcome: cognitive assessment scores (MMSE, SKT, NPI)
효과: None
None
대상 집단: patients with mild-to-moderate Alzheimer disease or vascular dementia
Review
Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: patients with vascular cognitive impairment and dementia
Review
The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Review of natural products for neuroprotection
Review
Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.
Dose: None
vs: None
Outcome: Cognitive function in multiple sclerosis
효과: None
None
대상 집단: Multiple sclerosis patients (review)
Review
Nutritional strategies against dementia in rural populations.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: Rural populations with dementia risk
Cohort Study
n=64
52 weeks
Open-label
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Dose: 240 mg/day
vs: Standard cognitive enhancers
Outcome: Cognitive responder rate and AD conversion
효과: 100% vs 59.1% responders; 0% vs 13.6% AD conversio
<0.001 (responders); 0.037 (AD
대상 집단: Amyloid PET-positive MCI patients
Key Statistics
40
연구
8000
참여자
↔
Mixed
C
등급
Referenced Papers
American journal of …
None
1 인용
Neuropsychopharmacology : official …
2026
1 인용
Journal of ethnopharmacology
2025
5 인용
Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment.
Other
Frontiers in neurology
2025
4 인용
Annals of medicine …
2025
3 인용
Handbook of experimental …
2025
1 인용
Frontiers in nutrition
2025
Degenerative neurological and …
2024
66 인용
Journal of Alzheimer's …
2024
12 인용
Current Alzheimer research
2024
10 인용
Dementia and geriatric …
2024
6 인용
Medicine
2024
3 인용
Food science & …
2024
3 인용
Biology
2023
37 인용
Scientific reports
2023
30 인용
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 인용
Biomolecules
2021
161 인용
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 인용
Pharmaceuticals (Basel, Switzerland)
2021
33 인용
The Effect of Polyphenols on Working and Episodic Memory in Non-pathological and Pathological Aging: A Systematic Review and Meta-Analysis.
Systematic Review
Frontiers in nutrition
2021
26 인용
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 인용
CNS & neurological …
2021
12 인용
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
2020
4 인용
Oxidative medicine and …
2019
102 인용
Prostaglandins, leukotrienes, and …
2019
5 인용
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Systematic Review
Annals of internal …
2018
119 인용
Acta bio-medica : …
2018
103 인용
Pharmacological research
2018
67 인용
Frontiers in nutrition
2018
18 인용
The journals of …
2017
97 인용
Journal of Alzheimer's …
2017
17 인용
Frontiers in aging …
2016
72 인용
Nutrients
2016
53 인용
Journal of the …
2016
16 인용
The American journal …
2015
204 인용
Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.
Meta-Analysis
Climacteric : the …
2015
92 인용
Age (Dordrecht, Netherlands)
2014
Clinical pharmacokinetics
2013
220 인용
CNS drugs
2013
138 인용
Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.
Other
PloS one
2013
73 인용
International psychogeriatrics
2012
29 인용
American family physician
2011
Experimental aging research
2010
21 인용
JAMA
2010
3 인용
The Practitioner
2010
JAMA
2009
304 인용
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2009
299 인용
Epidemiologic reviews
2008
172 인용
Neurology
2008
147 인용
The Canadian veterinary …
2008
Herbal drug treatment.
Review
Neuro endocrinology letters
2008
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2007
375 인용
The Proceedings of …
2002
191 인용
Ginkgo biloba for cognitive impairment and dementia.
Meta-Analysis
The Cochrane database …
2002
Alternative medicine review …
1999
112 인용
Current opinion in …
1998
30 인용
British journal of …
1993
8 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones
상한량: 600 mg/day (doses above show no additional benefit)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 240 mg/day | 52 weeks | Positive | 64 |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
권장 복용 시간: With meals; may require 4-6 weeks for full effects
Safety & Side Effects
보고된 부작용
- ⚠ Headache
- ⚠ Gastrointestinal upset
- ⚠ Dizziness
- ⚠ Allergic skin reactions (rare)
- ⚠ Increased bleeding risk
알려진 상호작용
- ● Anticoagulants and antiplatelet drugs (increased bleeding risk)
- ● Anticonvulsants (may reduce seizure threshold)
- ● SSRIs (serotonin syndrome risk, rare)
- ● CYP3A4 substrates (may affect drug metabolism)
일일 최대 섭취 허용량: 600 mg/day (doses above show no additional benefit)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Ginkgo biloba help with Age-Related Cognitive Decline?
Based on 40 studies with 8,000 participants, there is limited but promising evidence that Ginkgo biloba may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Ginkgo biloba should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ginkgo biloba?
Reported side effects may include Headache, Gastrointestinal upset, Dizziness, Allergic skin reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ginkgo biloba and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 40 peer-reviewed studies with 8,000 total participants. The overall direction of effect is mixed.
Related Evidence
관련 다른 성분: Age-Related Cognitive Decline
Ginkgo biloba 다른 건강 상태에 대한 근거
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