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Gotu Kola для Age-Related Cognitive Decline

D

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

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D

Итог

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

Key Study Findings

Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None или: None Outcome: Cholinesterase inhibition and cognitive improvement Эффект: None None

Популяция: In vivo animal models of AD

Controlled Clinical Trial
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day или: Control chow Outcome: Sleep quality and quantity (EEG/EMG) Эффект: None None

Популяция: 18-month-old male and female C57BL6/J mice

In Vitro
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …
Dose: None или: H2O2-induced oxidative stress Outcome: Neuroprotection and cognitive decline biomarkers Эффект: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2 None

Популяция: 3D intestinal model and neuronal/astrocytic co-culture

Other
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day или: Control chow Outcome: Sleep composition (REM/NREM duration, arousals) Эффект: None None

Популяция: Aged (18-month) C57BL6/J mice

Review
Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.
Dose: None или: None Outcome: DM and AD symptom management Эффект: None None

Популяция: Patients with diabetes and Alzheimer's disease (review)

Other
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Dose: None или: None Outcome: AChE and BACE1 inhibition for Alzheimer's Эффект: None None

Популяция: In silico AD drug discovery (820 metabolites screened)

Key Statistics

4

Исследования

200

Участники

Positive

D

Оценка

Referenced Papers

bioRxiv : the … 2025 1 цитирований
Biomolecules 2021 161 цитирований
Phytotherapy research : … 2007 256 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
500-1,000 mg/day standardized extract
cognitivesupport:
750 mg/day

Верхний предел: Not established; hepatotoxicity reported rarely at very high doses

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
1000 mg/kg/day -- Positive --
None -- Positive --
None -- Positive --
None -- Positive --
1 μg/mL -- Positive --

Лучшее время приёма: With meals

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Skin irritation (topical)
  • Headache
  • Gastrointestinal discomfort
  • Drowsiness
  • Rare: liver toxicity at very high doses

Известные взаимодействия

  • Hepatotoxic drugs (additive liver stress)
  • Sedative medications (additive CNS depression)
  • Cholesterol-lowering drugs (theoretical interaction)

Допустимый верхний уровень потребления: Not established; hepatotoxicity reported rarely at very high doses

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Gotu Kola help with Age-Related Cognitive Decline?
Based on 4 studies with 200 participants, there is preliminary evidence that needs more research that Gotu Kola may support Age-Related Cognitive Decline management. Our evidence grade is D (Very Early Research).
How much Gotu Kola should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Gotu Kola?
Reported side effects may include Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Gotu Kola and Age-Related Cognitive Decline?
We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.