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Omega-3 Fatty Acids (DHA/EPA) cho Cerebrovascular Health

B

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

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B

Kết luận

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

Key Study Findings

Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: narrative review of ashwagandha clinical trials and basic research (1994-present)

Other 10 weeks
Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of …
Dose: None so với: Untreated APP/PS1 mice Outcome: Cognitive performance in behavioral tests Hiệu quả: None None

Đối tượng nghiên cứu: APP/PS1 transgenic Alzheimer's disease mouse model

Review
Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines.
Dose: None so với: None Outcome: ASD symptom management Hiệu quả: None None

Đối tượng nghiên cứu: Children with autism spectrum disorder

Cohort Study n=215624
Neuroticism, omega-3 fatty acids, and risk of incident dementia.
Dose: None so với: None Outcome: Incident all-cause dementia Hiệu quả: None <0.05 (Bonferroni)

Đối tượng nghiên cứu: Dementia-free UK Biobank participants aged 40-69

preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL so với: Placebo Hiệu quả: None None
Other 26 weeks
Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk.
Dose: EPA 180mg + DHA 120mg so với: Simulated disease population baseline Outcome: Lipid biomarker changes (in silico model) Hiệu quả: 14.7% TG reduction, 22.38% HDL increase None

Đối tượng nghiên cứu: Simulated CVD disease population (in silico study)

Key Statistics

12

Nghiên cứu

2000

Người tham gia

Positive

B

Xếp hạng

Referenced Papers

Nutrients 2025 2 trích dẫn
Acta pharmaceutica Sinica. … 2024 33 trích dẫn
La Revue du … 2024
Nature reviews. Disease … 2021 163 trích dẫn
The Senior care … 2021 2 trích dẫn
Journal of ethnopharmacology 2020 85 trích dẫn
Current nutrition reports 2019 68 trích dẫn
Current neurology and … 2019 11 trích dẫn
Sleep medicine 2017 95 trích dẫn
Current treatment options … 2017 56 trích dẫn
Clinical therapeutics 2016 328 trích dẫn
Molecular nutrition & … 2015 18 trích dẫn
Journal of clinical … 2011 396 trích dẫn
Journal of psychosocial … 2011 26 trích dẫn
Journal of Alzheimer's … 2010 110 trích dẫn
The Practitioner 2010
The Cochrane database … 2003 263 trích dẫn
The Medical clinics … 2002 59 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:
1,000-2,000 mg combined DHA/EPA per day
cognitivesupport:
1,000-1,700 mg/day (optimal dose-response curve)

Giới hạn trên: 3,000 mg/day combined DHA/EPA (FDA GRAS)

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
None -- Positive --
None 10 weeks Positive --
None -- Positive --
None -- Positive 215624
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
EPA 180mg + DHA 120mg 26 weeks Positive --
None -- Mixed --
None -- Mixed --

Thời điểm dùng tốt nhất: With meals containing fat for better absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Fishy aftertaste or burping
  • Mild gastrointestinal discomfort
  • Potential increased bleeding time at very high doses
  • May lower blood pressure slightly

Tương tác đã biết

  • Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
  • Blood pressure medications (additive hypotensive effect)
  • Orlistat (may reduce omega-3 absorption)

Mức hấp thụ tối đa cho phép: 3,000 mg/day combined DHA/EPA (FDA GRAS)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?
Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.