Melatonin 用于 Sleep-Related Cognitive Impairment
CWell-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
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C
结论
Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.
Key Study Findings
review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other)
vs: Placebo
效果: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence
None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None
vs: PCPA-induced insomnia model control
Outcome: Sleep quality and cognitive function in rat model
效果: None
None
研究人群: PCPA-induced insomnia male rats
Randomized Controlled Trial
n=322
5 weeks
Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily
vs: Placebo
Outcome: Latency to persistent sleep (PSG)
效果: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo)
<0.001
研究人群: Patients with primary insomnia (sleep onset difficulty)
Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None
vs: None
Outcome: ISWRD symptom management
效果: None
None
研究人群: Patients with irregular sleep-wake rhythm disorder
review
Insomnia in older adults: A review of treatment options.
Dose: various
vs: Placebo
效果: None
None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None
vs: None
Outcome: Pain outcomes
效果: None
None
研究人群: Insomnia patients
Key Statistics
15
研究数量
2000
受试者
↑
Positive
C
等级
Referenced Papers
Pediatric Insomnia.
Review
Pediatrics in review
2026
Cleveland Clinic journal …
2025
12 次引用
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Review
Handbook of clinical …
2025
4 次引用
PloS one
2025
1 次引用
Neurochemical research
2025
Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis.
Meta-Analysis
JNCI cancer spectrum
2024
24 次引用
Journal of neurology
2024
21 次引用
Antioxidants (Basel, Switzerland)
2024
17 次引用
Current opinion in …
2024
12 次引用
Frontiers in medicine
2024
4 次引用
La Revue du …
2024
Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
Systematic Review
Journal of sleep …
2023
12 次引用
Journal of pineal …
2023
7 次引用
Frontiers in neuroscience
2023
5 次引用
Current drug safety
2023
2 次引用
BMJ open
2022
3 次引用
NPJ Parkinson's disease
2022
Progress in neuro-psychopharmacology …
2021
68 次引用
Frontiers in neurology
2021
16 次引用
A Systematic Review of the Efficacy and Safety of Over-the-Counter Medications Used in Older People for the Treatment of Primary …
Systematic Review
The Senior care …
2021
12 次引用
Neural regeneration research
2021
6 次引用
Climacteric : the …
2020
97 次引用
Neurotherapeutics : the …
2020
80 次引用
Current treatment options …
2020
29 次引用
Human brain mapping
2020
15 次引用
Dermatitis : contact, …
2019
7 次引用
Journal of sleep …
2017
1691 次引用
Neurological research
2017
331 次引用
Nutrients
2017
301 次引用
Current treatment options …
2017
56 次引用
Journal of pineal …
2017
45 次引用
Clinical therapeutics
2016
328 次引用
Pediatric Insomnia.
Review
Chest
2016
109 次引用
European heart journal. …
2016
77 次引用
Diabetes, obesity & …
2015
132 次引用
Alcohol (Fayetteville, N.Y.)
2015
122 次引用
Menopause (New York, …
2015
73 次引用
Chest
2013
53 次引用
PloS one
2012
14 次引用
Pharmacological reports : …
2011
99 次引用
Progress in neuro-psychopharmacology …
2011
71 次引用
Der Nervenarzt
2009
6 次引用
Pharmacotherapy
2007
117 次引用
Tidsskrift for den …
2006
Brain research. Molecular …
2005
160 次引用
Reviews of reproduction
1998
381 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 0.5-5 mg/day
- sleepcognitivesupport:
- 0.5-3 mg 30-60 min before bed
上限： 10 mg/day (higher doses not more effective)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) | -- | Positive | -- |
| None | -- | Positive | -- |
| 20 mg or 50 mg tasimelteon daily | 5 weeks | Positive | 322 |
| None | -- | Mixed | -- |
| various | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Positive | 6528 |
| Z-drugs, melatonin, orexin antagonists | -- | Positive | -- |
最佳服用时间： 30-60 minutes before bedtime
Safety & Side Effects
已报告的副作用
- ⚠ Daytime drowsiness
- ⚠ Headache
- ⚠ Dizziness
- ⚠ Nausea
- ⚠ Vivid dreams
已知相互作用
- ● Sedative medications (additive drowsiness)
- ● Blood thinners (may increase bleeding risk)
- ● Diabetes medications (may affect blood sugar)
- ● Immunosuppressants (may stimulate immune function)
- ● Oral contraceptives (may increase melatonin levels)
可耐受最高摄入量： 10 mg/day (higher doses not more effective)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Sleep-Related Cognitive Impairment
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