Uridine Monophosphate 用于 Neurotransmitter Imbalance

The uridine + DHA + choline combination (known as the 'Mr. Happy Stack') provides synergistic support for phospholipid synthesis and dopamine receptor expression. Limited but promising clinical evidence.

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结论

Key Study Findings

Observational Study

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Dogs with intervertebral disc herniation

In Vitro

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites.

Dose: None vs: LPS-treated astrocyte controls Outcome: Astrocyte gene expression and metabolite changes 效果: None None

研究人群: LPS-induced inflammatory astrocyte model

Review

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the …

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Other

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora …

Dose: None vs: None Outcome: None 效果: None P = 0.013

研究人群: Healthy adults

Other 4 weeks

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling …

Dose: 5 mg/kg vs: None Outcome: Cognitive function 效果: None None

研究人群: Sprague Dawley rats

In Vitro

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in …

Dose: 1 g vs: None Outcome: None 效果: None None

研究人群: None

Key Statistics

研究数量

300

受试者

↑

Positive

等级

Referenced Papers

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. Other

Metabolites 2025

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites. Other

Nutrients 2025

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis. Review

Pharmacological reports : … 2025

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons. Other

Drug design, development … 2024 8 次引用

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora disease. Other

Brain communications 2024 8 次引用

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in the Chinese Mitten Crab, Eriocheir … Other

International journal of … 2023 12 次引用

Citicoline for Supporting Memory in Aging Humans. Review

Aging and disease 2023 9 次引用

Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function. Other

EMBO reports 2023 5 次引用

The G Protein-Coupled Serotonin 1A Receptor Augments Protein Kinase Cε-Mediated Neurogenesis in Neonatal Mouse Hippocampus-PKCε-Mediated Signaling in the Early Hippocampus. Other

International journal of … 2022 4 次引用

Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment. Other

Neurochemistry international 2021 12 次引用

ATP as a cotransmitter in sympathetic and parasympathetic nerves - another Burnstock legacy. Other

Autonomic neuroscience : … 2021 9 次引用

Dexamethasone-Induced Perturbations in Tissue Metabolomics Revealed by Chemical Isotope Labeling LC-MS analysis. Other

Metabolites 2020 29 次引用

Vortioxetine: Clinical Pharmacokinetics and Drug Interactions. Review

Clinical pharmacokinetics 2018 128 次引用

Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal. Other

American journal of … 2017 14 次引用

Synapse formation in the brain can be enhanced by co-administering three specific nutrients. Other

European journal of … 2017 9 次引用

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Other

Neurobiology of disease 2016 83 次引用

Purinergic transmission in blood vessels. Review

Autonomic neuroscience : … 2015 81 次引用

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice. Other

Physiology & behavior 2015 45 次引用

Optimising nutrition to improve growth and reduce neurodisabilities in neonates at risk of neurological impairment, and children with suspected or … RCT

BMC pediatrics 2015 15 次引用

Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. Other

PloS one 2011 62 次引用

Non-nutritional uses of nutrients. Review

European journal of … 2011 16 次引用

Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats. Other

Stem cell research 2010 18 次引用

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Other

Experimental neurology 2009 170 次引用

Use of phosphatide precursors to promote synaptogenesis. Review

Annual review of … 2009 141 次引用

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Review

Alzheimer's & dementia … 2008 96 次引用

Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. Other

FASEB journal : … 2008 95 次引用

Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors. Other

Journal of neurochemistry 2008 91 次引用

Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. Other

Biotechnology and applied … 2008 7 次引用

HVC interneurons are not renewed in adult male zebra finches. Other

The European journal … 2007 55 次引用

Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina. Other

The Journal of … 2007 36 次引用

Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Other

Journal of molecular … 2005 66 次引用

P2X and P2Y receptors as possible targets of therapeutic manipulations in CNS illnesses. Review

Drug news & … 2005 43 次引用

Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling … Other

Neuropsychopharmacology : official … 2005 39 次引用

Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Other

Journal of neuroendocrinology 2002 83 次引用

Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. Other

Journal of neuroscience … 2002 58 次引用

Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients. Other

The Biochemical journal 2002 43 次引用

Calcium-dependent regulation of cholinergic cell phenotype in the hypothalamus in vitro. Other

Journal of neurophysiology 2002 27 次引用

Is there a role for uridine and pyrimidine nucleosides in the treatment of vascular dementia? Review

Functional neurology 2002

Identification and characterization of neuronal precursors and their progeny from human fetal tissue. Other

Journal of neuroscience … 2001 76 次引用

Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations. Other

Hormones and behavior 2001 45 次引用

Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. Other

The Journal of … 2000 745 次引用

Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. Other

The Journal of … 2000

Uridine activates fast transmembrane Ca2+ ion fluxes in rat brain homogenates. Other

Neuroreport 1999 32 次引用

GABA, GAD, and GABA(A) receptor alpha4, beta1, and gamma1 subunits are expressed in the late embryonic and early postnatal neocortical … Other

Microscopy research and … 1998 26 次引用

Neurogenesis and cell migration into the sexually dimorphic preoptic area/anterior hypothalamus of the fetal ferret. Other

Journal of neurobiology 1996 45 次引用

In vitro properties of a newly established medulloblastoma cell line, MCD-1. Other

Molecular and chemical … 1996 17 次引用

Ethanol neurotoxicity in culture: selective loss of cholinergic neurons. Other

Journal of neuroscience … 1996 16 次引用

Sleep as neuronal detoxification and restitution. Review

Behavioural brain research 1995 146 次引用

Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in … Other

Developmental biology 1989 100 次引用

Adrenal steroids as modulators of nerve cell function. Review

Journal of steroid … 1984 22 次引用

Neurons from fetal rat brain in a new cell culture system: a multidisciplinary analysis. Other

Brain research 1975 122 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 150-250 mg/day
cognitivesupport:: 250-500 mg sublingually

上限： Not established; well-tolerated up to 1,000 mg/day

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
5 mg/kg	4 weeks	Positive	--
1 g	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--

最佳服用时间： Morning; synergizes with DHA and choline sources

Safety & Side Effects

已报告的副作用

⚠ Mild gastrointestinal discomfort
⚠ Headache (rare)
⚠ Nervousness at high doses

已知相互作用

● No significant drug interactions established

可耐受最高摄入量： Not established; well-tolerated up to 1,000 mg/day

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Uridine Monophosphate help with Neurotransmitter Imbalance?

Based on 4 studies with 300 participants, there is limited but promising evidence that Uridine Monophosphate may support Neurotransmitter Imbalance management. Our evidence grade is C (Some Evidence).

How much Uridine Monophosphate should I take for Neurotransmitter Imbalance?

Studies have used various dosages. A commonly studied range is 150-250 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Uridine Monophosphate?

Reported side effects may include Mild gastrointestinal discomfort, Headache (rare), Nervousness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Uridine Monophosphate and Neurotransmitter Imbalance?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Neurotransmitter Imbalance

Alpha-GPC B Zinc C

快速结论

Evidence Strength52%

Moderate confidence

研究分析

RCT (1)Meta (0)Other (3)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Neurotransmitter Imbalance

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