Zinc 用于 Neurotransmitter Imbalance

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

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结论

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

Key Study Findings

Review

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.

Dose: None vs: None Outcome: association between zinc homeostasis and MDD pathology 效果: None None

研究人群: patients with major depressive disorder

Review

Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.

Dose: None vs: None Outcome: None 效果: None None

研究人群: People with depression

Other

Exogenous nanomolar zinc ion (Zn2+) as a negative modulator of neuromuscular transmission via presynaptic mechanism …

Dose: Nanomolar range vs: Without Zn2+ addition Outcome: Neuromuscular transmission and diaphragm function 效果: None None

研究人群: Mouse diaphragm (ex vivo and in vivo)

Review

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Observational Study

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Dogs with intervertebral disc herniation

Review

Magnesium and Zinc in Schizophrenia.

Dose: None vs: None Outcome: None 效果: None None

研究人群: Patients with schizophrenia

Key Statistics

研究数量

600

受试者

↑

Positive

等级

Referenced Papers

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications. Review

Annals of medicine 2026 1 次引用

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review. Review

Journal of neurochemistry 2025 8 次引用

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature. Review

American journal of … 2025 3 次引用

The Role of Various Types of Diets in the Treatments of Depressive Disorders. Review

Medicina (Kaunas, Lithuania) 2025 1 次引用

Magnesium and Zinc in Schizophrenia. Review

Biomedicines 2025

Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions. Other

Nature communications 2025

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. Other

Metabolites 2025

Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review. Review

International journal of … 2025

Exogenous nanomolar zinc ion (Zn2+) as a negative modulator of neuromuscular transmission via presynaptic mechanism in mouse diaphragm. Other

Biometals : an … 2025

Structure of the human dopamine transporter and mechanisms of inhibition. Other

Nature 2024 40 次引用

Molecular mechanisms of zinc oxide nanoparticles neurotoxicity. Review

Chemico-biological interactions 2024 14 次引用

Three classes of propofol binding sites on GABAA receptors. Other

The Journal of … 2024 9 次引用

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons. Other

Drug design, development … 2024 8 次引用

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies. Review

International journal of … 2024 7 次引用

Manganese- and zinc-coordinated interaction of Schistosoma japonicum glutathione S-transferase with neurotransmitter transporters GlyT1 and GAT3 in vitro. Other

Experimental parasitology 2024 2 次引用

Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to … Other

Journal of toxicology 2024 1 次引用

Consequences of Disturbing Manganese Homeostasis. Review

International journal of … 2023 120 次引用

Mechanisms of Cadmium Neurotoxicity. Review

International journal of … 2023 105 次引用

Depression in dementia with Lewy bodies: a critical update. Review

Journal of neural … 2023 22 次引用

Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease. Review

Pharmacology & therapeutics 2023 11 次引用

Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain. Review

International journal of … 2022 38 次引用

Rebuilding essential active zone functions within a synapse. Other

Neuron 2022 29 次引用

Neuronal signalling of zinc: from detection and modulation to function. Review

Open biology 2022 28 次引用

Zinc alters behavioral phenotypes, neurotransmitter signatures, and immune homeostasis in male zebrafish (Danio rerio). Other

The Science of … 2022 11 次引用

The Function and Regulation of Zinc in the Brain. Review

Neuroscience 2021 108 次引用

The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized … Systematic Review

Nutrients 2021 37 次引用

Zinc and Copper Brain Levels and Expression of Neurotransmitter Receptors in Two Rat ASD Models. Other

Frontiers in molecular … 2021 15 次引用

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 次引用

Effects of Zinc, Mercury, or Lead on [3H]MK-801 and [3H]Fluorowillardiine Binding to Rat Synaptic Membranes. Other

Neurochemical research 2021 1 次引用

Zinc. Review

Advances in food … 2021

Amperometric Measurements and Dynamic Models Reveal a Mechanism for How Zinc Alters Neurotransmitter Release. Other

Angewandte Chemie (International … 2020 28 次引用

Copper deficiency anemia: review article. Review

Annals of hematology 2018 234 次引用

[Nutrition strategies that improve cognitive function]. Review

Nutricion hospitalaria 2018 32 次引用

Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function. Review

Neuroscience and biobehavioral … 2017 138 次引用

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies. Review

Frontiers in neuroscience 2017 58 次引用

Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer. Review

Current pharmaceutical design 2017 37 次引用

The zinc paradigm for metalloneurochemistry. Review

Essays in biochemistry 2017 19 次引用

Smart Contrast Agents for Magnetic Resonance Imaging. Review

Chimia 2016 21 次引用

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Other

Molecular nutrition & … 2015 18 次引用

[Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms]. Other

Minerva ginecologica 2015 4 次引用

Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases. Review

Biometals : an … 2014 72 次引用

Cadmium and its neurotoxic effects. Review

Oxidative medicine and … 2013 520 次引用

Glutamate receptors, neurotoxicity and neurodegeneration. Review

Pflugers Archiv : … 2010 1150 次引用

Role of zinc in the development and treatment of mood disorders. Review

Current opinion in … 2010 77 次引用

RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia. Review

Metabolic brain disease 2009 42 次引用

Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus. Review

Neurotoxicity research 2008 121 次引用

Metals and neurotoxicology. Review

The Journal of … 2007 245 次引用

Zn2+ modulation of neurotransmitter transporters. Review

Handbook of experimental … 2006 22 次引用

Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. Other

Journal of neuroscience … 2004 115 次引用

[Essential trace metals and brain function]. Review

Yakugaku zasshi : … 2004 36 次引用

Atypical neural messengers. Review

Trends in neurosciences 2001 285 次引用

Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Review

Biochemistry. Biokhimiia 2000 110 次引用

Bacterial toxins with intracellular protease activity. Review

Clinica chimica acta; … 2000 31 次引用

Zinc and the central nervous system. Review

Progress in food … 1987 48 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 8-11 mg/day (RDA)
cognitivesupport:: 15-30 mg/day

上限： 40 mg/day (GI effects, copper depletion above)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Mixed	--
Nanomolar range	--	Negative	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--

最佳服用时间： With meals to reduce GI effects; separate from iron by 2 hours

Safety & Side Effects

已报告的副作用

⚠ Nausea on empty stomach
⚠ Copper deficiency at chronic high doses
⚠ Metallic taste
⚠ Headache

已知相互作用

● Antibiotics (quinolones, tetracyclines — reduced absorption)
● Penicillamine (reduced absorption of both)
● Iron supplements (competitive absorption)

可耐受最高摄入量： 40 mg/day (GI effects, copper depletion above)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Zinc help with Neurotransmitter Imbalance?

Based on 8 studies with 600 participants, there is limited but promising evidence that Zinc may support Neurotransmitter Imbalance management. Our evidence grade is C (Some Evidence).

How much Zinc should I take for Neurotransmitter Imbalance?

Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc?

Reported side effects may include Nausea on empty stomach, Copper deficiency at chronic high doses, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc and Neurotransmitter Imbalance?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Neurotransmitter Imbalance

Alpha-GPC B Uridine Monophosphate C

快速结论

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

Evidence Strength52%

Moderate confidence

研究分析

RCT (0)Meta (0)Other (8)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Neurotransmitter Imbalance

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