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Taurine für Oxidative Stress & Neuroinflammation

C

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

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Fazit

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

Key Study Findings

Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: narrative review of taurine neuroprotective actions in Alzheimer's disease

Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None vs.: untreated 3xTg-AD mice Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism) Wirkung: None None

Population: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice

Controlled Clinical Trial 6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day vs.: ROFA exposure without taurine Outcome: Multi-organ oxidative stress and neuroinflammation Wirkung: None None

Population: Male Wistar rats with intranasal ROFA exposure

Other n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None vs.: Rotenone-induced PD model controls Outcome: Neuroprotection in rotenone-induced PD mice Wirkung: None None

Population: Rotenone-induced Parkinson's disease mice (10 groups)

Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None vs.: HSV-1 infected cells/mice without taurine Outcome: HSV-1 infection and viral encephalitis severity Wirkung: None None

Population: HSV-1 viral encephalitis in vitro and mouse model

Other 4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks vs.: Vehicle control in 5XFAD mice Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation Wirkung: None None

Population: 5XFAD AD mice and patient-derived cerebral organoids

Key Statistics

6

Studien

300

Teilnehmer

Positive

C

Bewertung

Referenced Papers

Psychoneuroendocrinology 2025 1 Zitierungen
NPJ Parkinson's disease 2024 57 Zitierungen
Alcohol (Fayetteville, N.Y.) 2015 122 Zitierungen
Frontiers in bioscience … 2015 62 Zitierungen
British journal of … 2014 111 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
500-2,000 mg/day
cognitivesupport:
1,000-3,000 mg/day

Obergrenze: 3,000 mg/day (EFSA safety assessment)

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Positive --
None -- Positive --
400 mg/kg/day 6 weeks Mixed --
None -- Positive 70
None -- Positive --
1000 mg/kg oral for 4 weeks 4 weeks Positive --
None -- Mixed --
None -- Mixed --

Beste Einnahmezeit: With or without food; may be calming if taken evening

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Generally very well-tolerated
  • Mild gastrointestinal discomfort (rare)
  • Drowsiness at high doses

Bekannte Wechselwirkungen

  • Antihypertensive drugs (additive blood pressure lowering)
  • Antiepileptic drugs (may enhance GABA effects)

Tolerierbare Höchstaufnahmemenge: 3,000 mg/day (EFSA safety assessment)

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

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