What is the recommended dosage for Resveratrol?

General: 150-500 mg/day trans-resveratrol; Cognitive Support: 200-500 mg/day

What are the side effects of Resveratrol?

Potential side effects include: Gastrointestinal discomfort, Headache, Diarrhea at high doses.

Resveratrol is a polyphenol found in red grapes, berries, and peanuts. It has been studied for its antioxidant and anti-inflammatory properties, with research exploring its potential to support cerebral blood flow, reduce neuroinflammation, and protect against age-related cognitive changes.

What dosage of Resveratrol has been used in cognitive studies?

Cognitive studies have used 75 mg to 500 mg of resveratrol daily. Trans-resveratrol is the more bioactive form. Some studies use higher doses (up to 1,000 mg), though bioavailability is a challenge with standard formulations. Consult your healthcare provider for guidance.

What are the potential side effects of Resveratrol?

Resveratrol is generally well tolerated at moderate doses. Gastrointestinal symptoms such as nausea, diarrhea, and stomach cramps have been reported at high doses. It may interact with blood-thinning medications and CYP450 enzyme substrates. Consult your healthcare provider before use.

Resveratrol

antioxidant

Also known as: Trans-Resveratrol, 3,5,4'-Trihydroxystilbene

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About

Resveratrol activates SIRT1 and AMPK pathways that support cellular stress resistance and enhances cerebral blood flow through nitric oxide-mediated vasodilation. Clinical evidence suggests it may improve memory and cognitive performance in older adults.

How It Works

Activates SIRT1 and AMPK pathways supporting cellular stress resistance; enhances cerebral blood flow through NO-mediated vasodilation; reduces neuroinflammation and beta-amyloid aggregation.

Evidence For Conditions

Condition	Grade	Studies	Participants
Cerebrovascular Health	C	8	600	View →

Side Effects

Gastrointestinal discomfort
Headache
Diarrhea at high doses

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
CYP450 substrates (affects drug metabolism)
Estrogen-sensitive conditions (weak estrogenic activity)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Alpha-Lipoic Acid Astaxanthin Coenzyme Q10 Curcumin Lutein & Zeaxanthin

Quick Facts

Dosage: General: 150-500 mg/day trans-resveratrol; Cognitive_Support: 200-500 mg/day
Forms: capsule tablet powder liquid
Natural Sources: Red grapes, Red wine, Blueberries, Peanuts, Dark chocolate, Japanese knotweed
Upper Limit: 5,000 mg/day (highest dose in clinical trials)
Best Time: With meals containing fat; morning preferred

Evidence Summary

Cerebrovascular Health C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.