Vitamin D per Nutritional Deficiency Cognitive Impairment

Q: Does Vitamin D help with Nutritional Deficiency Cognitive Impairment?

Based on 20 studies with 4,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).

Q: How much Vitamin D should I take for Nutritional Deficiency Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Vitamin D and Nutritional Deficiency Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 4,500 total participants. The overall direction of effect is positive.

Vitamin D deficiency is identified as a critical risk factor for cognitive decline. 40% of geriatric memory clinic patients are D-deficient. Co-supplementation with B12 and folate appears to provide synergistic cognitive support.

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Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None vs: None Outcome: Cognitive impairment risk Effetto: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Popolazione: Elderly participants aged 60+ from NHANES 2011-2014

Review

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.

Dose: None vs: None Outcome: Pregnancy outcomes and offspring neurodevelopment Effetto: None None

Popolazione: Pregnant women (review)

Meta-Analysis

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …

Dose: None vs: Control Outcome: Cognitive function Effetto: SMD = 0.58, 95% CI = [0.20, 0.96] P = 0.003

Popolazione: Patients with mild cognitive impairment

Other

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.

Dose: 75 mg vs: None Outcome: Body weight Effetto: None P < 0.05

Popolazione: Rat model

Controlled Clinical Trial

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.

Dose: None vs: None Outcome: neuroprotection Effetto: None None

Popolazione: None

RCT n=65 36 weeks Double-blind

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …

Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi vs: Placebo Effetto: significant improvement in cognitive fatigue (FIS-40); p = 0.0338 0.0338

Key Statistics

Studi

4500

Partecipanti

↑

Positive

Grado

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. Review

The Proceedings of … 2025 5 citazioni

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 citazioni

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. Other

Poultry science 2024 9 citazioni

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2023 9 citazioni

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. Other

Frontiers in neuroscience 2023 5 citazioni

Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … Other

Journal of cosmetic … 2023 3 citazioni

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 citazioni

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Meta-Analysis

The Cochrane database … 2018 123 citazioni

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 citazioni

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. Review

The journal of … 2015 25 citazioni

[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. Review

Der Internist 2015 3 citazioni

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citazioni

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 600-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day

Limite massimo: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	2582
None	--	Positive	--
None	--	Positive	--
75 mg	--	Neutral	--
None	--	Positive	--
4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi	36 weeks	Positive	65
None	--	Negative	90
50000 IU/week	9 weeks	Positive	619

Momento migliore per l'assunzione: With meals containing fat; morning preferred

Safety & Side Effects

Effetti collaterali segnalati

⚠ Hypercalcemia at very high doses
⚠ Nausea and vomiting
⚠ Kidney stones (rare, high doses)
⚠ Weakness and fatigue

Interazioni note

● Corticosteroids (reduce calcium absorption)
● Statins (both affect cholesterol pathways)
● Thiazide diuretics (additive calcium retention)
● Weight loss drugs (may reduce vitamin D absorption)

Livello di assunzione massimo tollerabile: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Vitamin D help with Nutritional Deficiency Cognitive Impairment?

Based on 20 studies with 4,500 participants, there is moderate evidence from clinical studies that Vitamin D may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).

How much Vitamin D should I take for Nutritional Deficiency Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Nutritional Deficiency Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 4,500 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Nutritional Deficiency Cognitive Impairment

Vitamin B12 A Folate B

Vitamin D per altre condizioni

Depression-Related Cognitive Dysfunction C

Verdetto rapido

Evidence Strength72%

High confidence

Analisi degli studi

RCT (1)Meta (2)Other (17)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Nutritional Deficiency Cognitive Impairment

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.