Vitamin B12 ： Nutritional Deficiency Cognitive Impairment
AA study of 202 people with cognitive impairment and low B12 levels found supplementation improved cognition in 84% of patients and memory/attention scores in 78%. Subclinical low-normal B12 is associated with increased risk of neurodegenerative conditions.
結論
A study of 202 people with cognitive impairment and low B12 levels found supplementation improved cognition in 84% of patients and memory/attention scores in 78%. Subclinical low-normal B12 is associated with increased risk of neurodegenerative conditions.
Key Study Findings
対象集団: Elderly participants aged 60+ from NHANES 2011-2014
対象集団: Adult stroke survivors (20 trials + 14 observational)
対象集団: Adults with vitamin B12 deficiency
対象集団: Pregnant women (review)
対象集団: Early Parkinson's disease patients
対象集団: Older adults and at-risk B12 deficient individuals
Key Statistics
25
研究数
3500
参加者数
Positive
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 2.4 mcg/day (RDA)
- deficiency:
- 1,000-2,000 mcg/day
- cognitivesupport:
- 500-1,000 mcg/day
上限量： No established UL (water-soluble, low toxicity)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： Morning, on empty stomach for better absorption (sublingual)
Safety & Side Effects
報告されている副作用
- ⚠ Generally very well-tolerated
- ⚠ Rare: acne-like eruptions at high doses
- ⚠ Injection site reactions (injectable form)
既知の相互作用
- ● Metformin (reduces B12 absorption)
- ● Proton pump inhibitors (reduce B12 absorption)
- ● Colchicine (reduces B12 absorption)
耐容上限摂取量： No established UL (water-soluble, low toxicity)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Vitamin B12 help with Nutritional Deficiency Cognitive Impairment?
How much Vitamin B12 should I take for Nutritional Deficiency Cognitive Impairment?
Are there side effects of Vitamin B12?
How strong is the evidence for Vitamin B12 and Nutritional Deficiency Cognitive Impairment?
Related Evidence
に関する他の成分： Nutritional Deficiency Cognitive Impairment
Vitamin B12 他の症状・状態について
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