Resveratrol 用于 Cerebrovascular Health

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

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结论

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

Key Study Findings

Systematic Review

Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: …

Dose: None vs: None Outcome: effects on glymphatic function, BBB permeability, neuroglial health 效果: None None

研究人群: experimental models and clinical trials on Alzheimer's, Parkinson's, and multiple sclerosis

Review

Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …

Dose: None vs: None Outcome: None 效果: None None

研究人群: older adults and individuals with neurodegenerative disorders

In Vitro

Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells.

Dose: None vs: CoCl2-induced hypoxia without resveratrol Outcome: Cell viability and Kbhb modulation under hypoxia 效果: None None

研究人群: PC12 rat pheochromocytoma cells

Review

Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease.

Dose: None vs: None Outcome: None 效果: None None

研究人群: None

Controlled Clinical Trial

[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on …

Dose: 40 or 60 mg/kg vs: CLP group (0.9% NaCl) Outcome: Cerebrovascular endothelial barrier function 效果: None None

研究人群: CLP-induced sepsis-associated encephalopathy mice

Systematic Review

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.

Dose: None vs: Placebo or no treatment Outcome: Cardiometabolic changes in menopausal women 效果: None None

研究人群: Menopausal women

Key Statistics

研究数量

600

受试者

↑

Positive

等级

Referenced Papers

Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review. Systematic Review

Brain research 2026 2 次引用

Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … Review

Phytotherapy research : … 2026

Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells. Other

BMC neurology 2025 3 次引用

The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. Review

Phytotherapy research : … 2025 1 次引用

The Nrf2-GPX4 axis mitigates ferroptosis-driven early brain injury in experimental subarachnoid hemorrhage. Other

Brain research 2025 1 次引用

Varicella Zoster Virus and Stroke: An Intricate Relationship. Review

Viruses 2025 1 次引用

[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on network pharmacology and experiment]. Other

Zhongguo Zhong yao … 2025

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. Other

Cardiovascular & hematological … 2025

Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease. Review

Phytotherapy research : … 2025

Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women. Other

Journal of applied … 2025

Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics. Review

Frontiers in pharmacology 2024 14 次引用

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine. Other

International journal of … 2024 1 次引用

Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS … Other

Aging 2023 3 次引用

Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study. Other

IBRO neuroscience reports 2023 1 次引用

The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. Systematic Review

Journal of medicinal … 2022 48 次引用

Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. Review

Frontiers in pharmacology 2022 37 次引用

Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects. Review

Biomedicine & pharmacotherapy … 2022 34 次引用

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency. Other

Cellular and molecular … 2022 20 次引用

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies. Systematic Review

Phytotherapy research : … 2022 13 次引用

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. Other

Acta biochimica Polonica 2022 10 次引用

A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine. RCT

Nutrients 2022 9 次引用

Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. Other

Nutrients 2022 2 次引用

Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover … RCT

Clinical nutrition (Edinburgh, … 2021 54 次引用

The Role of Resveratrol Administration in Human Obesity. Review

International journal of … 2021 50 次引用

Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke. Review

Frontiers in cellular … 2021 40 次引用

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. RCT

Journal of bone … 2020 120 次引用

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Other

Nutrients 2020 49 次引用

Resveratrol ameliorates brain injury via the TGF-β-mediated ERK signaling pathway in a rat model of cerebral hemorrhage. Other

Experimental and therapeutic … 2019 25 次引用

Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection. Review

International journal of … 2019 11 次引用

Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise. Review

Nutrients 2018 108 次引用

Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Review

Nutrients 2018 77 次引用

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease. Review

The American journal … 2018 29 次引用

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Other

Frontiers in aging … 2018 23 次引用

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. RCT

Nutrients 2017 149 次引用

Dietary Polyphenols in the Prevention of Stroke. Review

Oxidative medicine and … 2017 87 次引用

Resveratrol supplementation reduces pain experience by postmenopausal women. RCT

Menopause (New York, … 2017 47 次引用

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus. RCT

Nutrition, metabolism, and … 2016 85 次引用

Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. RCT

Nutrients 2016 83 次引用

Clinical Evaluation of Effects of Chronic Resveratrol Supplementation on Cerebrovascular Function, Cognition, Mood, Physical Function and General Well-Being in Postmenopausal … RCT

Nutrients 2016 38 次引用

[The role of resveratrol in the regulation of cell metabolism--a review]. Review

Postepy higieny i … 2016 13 次引用

Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults. Other

Journal of agricultural … 2014 58 次引用

Role of red grape polyphenols as antidiabetic agents. Review

Integrative medicine research 2014 51 次引用

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Review

Food and chemical … 2013 188 次引用

Evidence for circulatory benefits of resveratrol in humans. Review

Annals of the … 2013 31 次引用

Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells. Other

Journal of cerebral … 2011 61 次引用

Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Other

American journal of … 2011 60 次引用

Ageing and neurodegenerative diseases. Review

Ageing research reviews 2010 228 次引用

Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to … Other

The Journal of … 2010 83 次引用

Longevity nutrients resveratrol, wines and grapes. Other

Genes & nutrition 2010 64 次引用

Grapes, wines, resveratrol, and heart health. Review

Journal of cardiovascular … 2009 297 次引用

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. Review

Alcoholism, clinical and … 2009 238 次引用

Resveratrol preserves cerebrovascular density and cognitive function in aging mice. Other

Frontiers in aging … 2009

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 150-500 mg/day trans-resveratrol
cognitivesupport:: 200-500 mg/day

上限： 5,000 mg/day (highest dose in clinical trials)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
40 or 60 mg/kg	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
250 mg single dose	--	Positive	16

最佳服用时间： With meals containing fat; morning preferred

Safety & Side Effects

已报告的副作用

⚠ Gastrointestinal discomfort
⚠ Headache
⚠ Diarrhea at high doses

已知相互作用

● Anticoagulants (may increase bleeding risk)
● CYP450 substrates (affects drug metabolism)
● Estrogen-sensitive conditions (weak estrogenic activity)

可耐受最高摄入量： 5,000 mg/day (highest dose in clinical trials)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Resveratrol help with Cerebrovascular Health?

Based on 8 studies with 600 participants, there is limited but promising evidence that Resveratrol may support Cerebrovascular Health management. Our evidence grade is C (Some Evidence).

How much Resveratrol should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 150-500 mg/day trans-resveratrol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort, Headache, Diarrhea at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and Cerebrovascular Health?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Cerebrovascular Health

Omega-3 Fatty Acids (DHA/EPA) B Ginkgo biloba B

快速结论

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

Evidence Strength52%

Moderate confidence

研究分析

RCT (8)Meta (0)Other (0)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Cerebrovascular Health

了解更多

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