What is the recommended dosage for Alpha-Lipoic Acid?

General: 300-600 mg/day; Cognitive Support: 600-1,200 mg/day (R-ALA preferred)

What are the side effects of Alpha-Lipoic Acid?

Potential side effects include: Gastrointestinal discomfort, Skin rash, Hypoglycemia (in diabetics), Headache.

What is Alpha-Lipoic Acid?

Alpha-lipoic acid (ALA) is a naturally occurring antioxidant that functions in both water- and fat-soluble environments. It has been studied for its potential neuroprotective properties, including supporting mitochondrial function and reducing oxidative stress in the brain.

What dosage of Alpha-Lipoic Acid has been used in studies?

Cognitive studies have typically used 300 mg to 600 mg of alpha-lipoic acid daily. Some neuropathy trials have used up to 1,200 mg per day. R-alpha-lipoic acid, the naturally occurring form, may be effective at lower doses. Consult your healthcare provider for guidance.

What are the potential side effects of Alpha-Lipoic Acid?

Side effects may include nausea, skin rash, and stomach discomfort. Alpha-lipoic acid may lower blood sugar levels, so individuals with diabetes or those taking blood sugar-lowering medications should exercise caution and consult their doctor.

Alpha-Lipoic Acid

antioxidant

Also known as: ALA, Thioctic Acid, R-Lipoic Acid, R-ALA

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About

Alpha-Lipoic Acid is a universal antioxidant active in both water and fat environments. It regenerates other antioxidants and chelates redox-active metals, reducing oxidative neuronal damage. The ALCAR + ALA combination shows significant synergistic effects.

How It Works

Universal antioxidant active in both water-soluble and fat-soluble environments; regenerates other antioxidants (vitamins C, E, glutathione, CoQ10); chelates redox-active metals reducing oxidative neuronal damage.

Evidence For Conditions

Condition	Grade	Studies	Participants
Oxidative Stress & Neuroinflammation	C	8	500	View →

Side Effects

Gastrointestinal discomfort
Skin rash
Hypoglycemia (in diabetics)
Headache

Drug & Supplement Interactions

Antidiabetic drugs (may enhance blood sugar lowering)
Thyroid medications (may affect thyroid hormone levels)
Chemotherapy agents (may reduce efficacy of some agents)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Astaxanthin Coenzyme Q10 Curcumin Lutein & Zeaxanthin PQQ (Pyrroloquinoline Quinone)

Quick Facts

Dosage: General: 300-600 mg/day; Cognitive_Support: 600-1,200 mg/day (R-ALA preferred)
Forms: capsule tablet
Natural Sources: Organ meats, Spinach, Broccoli, Yams, Potatoes
Upper Limit: 2,400 mg/day (highest dose in clinical trials)
Best Time: On empty stomach; 30 minutes before meals

Evidence Summary

Oxidative Stress & Neuroinflammation C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.