What is the recommended dosage for Lion's Mane Mushroom?

General: 500-3,000 mg/day; Cognitive Support: 1,000-3,000 mg/day of fruiting body extract

What are the side effects of Lion's Mane Mushroom?

Potential side effects include: Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations.

Lion's mane (Hericium erinaceus) is an edible medicinal mushroom that contains compounds called hericenones and erinacines. These compounds have been shown in preclinical research to stimulate nerve growth factor (NGF) synthesis, and human studies have explored its potential to support memory and cognitive function.

What dosage of Lion's Mane has been used in studies?

Clinical trials have used 750 mg to 3,000 mg of lion's mane powder or extract daily, often divided into three doses. Both fruiting body and mycelium-based supplements have been studied. Consult your healthcare provider for personalized dosing recommendations.

What are the potential side effects of Lion's Mane?

Lion's mane is generally well tolerated. Mild side effects may include digestive discomfort and skin irritation in sensitive individuals. People with mushroom allergies should avoid it. It may interact with anticoagulant and antidiabetic medications. Consult your healthcare provider.

Lion's Mane Mushroom

mushroom

Also known as: Hericium erinaceus, Yamabushitake, Monkey Head Mushroom, Bearded Tooth

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About

Lion's Mane (Hericium erinaceus) is a medicinal mushroom containing bioactive hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis. Research suggests it may support neurogenesis, myelination, and hippocampal function. A landmark RCT in older adults with mild cognitive impairment showed significant cognitive improvement after 16 weeks.

How It Works

Contains bioactive hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis; promotes neurogenesis and myelination; supports hippocampal function and neuroplasticity.

Evidence For Conditions

Condition	Grade	Studies	Participants
Mild Cognitive Impairment (MCI)	B	6	400	View →
Memory Loss	C	5	350	View →
Brain Fog	C	4	250	View →

Side Effects

Mild gastrointestinal discomfort
Skin rash in rare cases (especially with allergies to mushrooms)
Potential itching or tingling sensations

Drug & Supplement Interactions

Anticoagulants (may have mild antiplatelet effects)
Antidiabetic medications (may lower blood sugar)
Immunosuppressants (may modulate immune function)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Cordyceps

Quick Facts

Dosage: General: 500-3,000 mg/day; Cognitive_Support: 1,000-3,000 mg/day of fruiting body extract
Forms: capsule powder liquid extract whole mushroom
Natural Sources: Hericium erinaceus fruiting body
Upper Limit: Not established; well-tolerated up to 3,000 mg/day
Best Time: With meals; effects observed after 8-16 weeks of consistent use

Evidence Summary

Mild Cognitive Impairment (MCI) B

Memory Loss C

Brain Fog C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.