What is the recommended dosage for Melatonin?

General: 0.5-5 mg/day; Sleep Cognitive Support: 0.5-3 mg 30-60 min before bed

What are the side effects of Melatonin?

Potential side effects include: Daytime drowsiness, Headache, Dizziness, Nausea, Vivid dreams.

Melatonin is a hormone naturally produced by the pineal gland that regulates the sleep-wake cycle. Beyond sleep, research suggests melatonin has antioxidant and neuroprotective properties. Adequate sleep quality, which melatonin supports, is critical for memory consolidation and cognitive function.

What dosage of Melatonin has been used in studies?

Sleep and cognitive studies have used doses ranging from 0.3 mg to 10 mg, typically taken 30 to 60 minutes before bedtime. Research suggests lower doses (0.5 mg to 3 mg) are often sufficient for sleep support. Consult your healthcare provider for personalized dosing.

What are the potential side effects of Melatonin?

Common side effects include daytime drowsiness, headache, and dizziness. Melatonin may interact with blood-thinning medications, diabetes drugs, immunosuppressants, and contraceptives. Long-term high-dose use has not been extensively studied. Consult your healthcare provider.

Melatonin

hormone_precursor

Also known as: N-Acetyl-5-Methoxytryptamine

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About

Melatonin is a neurohormone that regulates circadian rhythm critical for memory consolidation during sleep. It supports glymphatic system clearance of beta-amyloid and metabolic waste, and is a potent antioxidant in the brain.

How It Works

Regulates circadian rhythm critical for memory consolidation; potent antioxidant that scavenges reactive oxygen species in the brain; modulates GABA-A receptors; supports glymphatic clearance of beta-amyloid during sleep.

Evidence For Conditions

Condition	Grade	Studies	Participants
Sleep-Related Cognitive Impairment	C	15	2000	View →

Side Effects

Daytime drowsiness
Headache
Dizziness
Nausea
Vivid dreams

Drug & Supplement Interactions

Sedative medications (additive drowsiness)
Blood thinners (may increase bleeding risk)
Diabetes medications (may affect blood sugar)
Immunosuppressants (may stimulate immune function)
Oral contraceptives (may increase melatonin levels)

Always inform your healthcare provider about all supplements you take.

Quick Facts

Dosage: General: 0.5-5 mg/day; Sleep_Cognitive_Support: 0.5-3 mg 30-60 min before bed
Forms: tablet sublingual capsule gummy liquid
Natural Sources: Tart cherries, Walnuts, Tomatoes, Milk
Upper Limit: 10 mg/day (higher doses not more effective)
Best Time: 30-60 minutes before bedtime

Evidence Summary

Sleep-Related Cognitive Impairment C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.