Bacopa monnieri 관련 Age-Related Cognitive Decline

A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'ingredient\u003Dbacopa\u002Dmonnieri\u0026condition\u003Dcognitive\u002Ddecline'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

결론

Key Study Findings

Randomized Controlled Trial 6 weeks Double-blind

Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in …

Dose: 120 mL twice daily for 45 days vs: placebo Outcome: telomerase activity and telomere length 효과: None None

대상 집단: elderly participants with MoCA score >=24

Randomized Controlled Trial n=76 12 weeks Double-blind

Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients …

Dose: 300 mg/day standardized Bacopa monnieri extract vs: placebo Outcome: change in composite z score of memory at … 효과: None None

대상 집단: patients with amnestic mild cognitive impairment, mean age 62.2 years, 88.3% men

Other

Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus …

Dose: 200 mg/kg body weight vs: Rotenone-PD mice without BME Outcome: Recognition memory and AMPA receptor expression 효과: None None

대상 집단: Rotenone-induced Parkinson's disease mouse model

Systematic Review

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.

Dose: None vs: None Outcome: Cholinesterase inhibition and cognitive improvement 효과: None None

대상 집단: In vivo animal models of AD

Other

A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via …

Dose: None vs: Donepezil, Estradiol Outcome: Neurotherapeutic activity via ESR1 and ACHE 효과: None None

대상 집단: In silico AD modeling (systems biology)

Systematic Review n=1861

The effect of plant active substances on cognitive function in healthy older adults: a systematic …

Dose: None vs: Placebo or no intervention Outcome: Cognitive function (learning, memory, executive) 효과: Raisin SUCRA 95.1%; tart cherry 89.5% for memory None

대상 집단: Healthy older adults

Key Statistics

연구

1200

참여자

↑

Positive

등급

Referenced Papers

Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in relation to constitution (Prakriti) in … Other

Frontiers in medicine 2026

Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment … Other

JMIR research protocols 2026

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review. Review

Brain sciences 2025 14 인용

A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via estrogen signaling and cholinergic modulation. Other

Inflammopharmacology 2025 4 인용

Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus Are Associated with Recognition Memory … Other

Molecular neurobiology 2025 3 인용

The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of … Systematic Review

Frontiers in pharmacology 2025

Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration. Review

Current Alzheimer research 2024 10 인용

A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with … Systematic Review

Systematic reviews 2023 10 인용

Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by Bacopa monnieri. Other

Journal of complementary … 2022 3 인용

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 인용

Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. Systematic Review

Journal of alternative … 2021 13 인용

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 인용

Protocols for cognitive enhancement. A user manual for Brain Health Services-part 5 of 6. Other

Alzheimer's research & … 2021 1 인용

Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical … Review

Drug target insights 2019 103 인용

Botanicals and phytochemicals active on cognitive decline: The clinical evidence. Review

Pharmacological research 2018 67 인용

Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A … RCT

The journal of … 2017 30 인용

Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. Other

Medical hypotheses 2016 6 인용

Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. Review

Evidence-based complementary and … 2015 82 인용

Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. RCT

Clinical drug investigation 2014 54 인용

Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. Review

CNS drugs 2013 138 인용

Neuroprotective effects of Bacopa monnieri in experimental model of dementia. Other

Neurochemical research 2012 85 인용

A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning … RCT

Nutrition journal 2012 55 인용

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 인용

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:: 300-600 mg/day standardized to 50% bacosides
memorysupport:: 300 mg/day for minimum 8-12 weeks

상한량: Not established; well-tolerated up to 600 mg/day in trials

연구에서 사용된 용량

용량	기간	효과	N
120 mL twice daily for 45 days	6 weeks	Neutral	--
300 mg/day standardized Bacopa monnieri extract	12 weeks	Neutral	76
200 mg/kg body weight	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	1861
None	--	Mixed	--
None	12 weeks	Positive	--

권장 복용 시간: With meals; effects require 8-12 weeks of consistent use

Safety & Side Effects

보고된 부작용

⚠ Gastrointestinal discomfort (nausea, cramping, diarrhea)
⚠ Dry mouth
⚠ Fatigue in some individuals
⚠ Mild sedation at higher doses

알려진 상호작용

● Thyroid medications (may increase thyroid hormone levels)
● Anticholinergic drugs (opposes cholinergic enhancement)
● Sedative medications (additive CNS depression)
● Calcium channel blockers (may enhance blood pressure lowering)

일일 최대 섭취 허용량: Not established; well-tolerated up to 600 mg/day in trials

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does Bacopa monnieri help with Age-Related Cognitive Decline?

Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Bacopa monnieri may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).

How much Bacopa monnieri should I take for Age-Related Cognitive Decline?

Studies have used various dosages. A commonly studied range is 300-600 mg/day standardized to 50% bacosides. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Bacopa monnieri?

Reported side effects may include Gastrointestinal discomfort (nausea, cramping, diarrhea), Dry mouth, Fatigue in some individuals, Mild sedation at higher doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Bacopa monnieri and Age-Related Cognitive Decline?

We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.

Related Evidence

Bacopa monnieri 다른 건강 상태에 대한 근거

Memory Loss A Attention & Focus Difficulties C

한눈에 보기

Evidence Strength72%

High confidence

연구 분석

RCT (3)Meta (0)Other (12)

대안 비교

이 건강 상태에 대한 다른 성분의 비교 결과를 확인하세요.

모든 성분 보기: Age-Related Cognitive Decline

자세히 알아보기

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.