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Phosphatidylserine для Age-Related Cognitive Decline

B

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

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Итог

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

Key Study Findings

Other
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
Dose: None или: None Outcome: astrocytic lipophagy and cognitive function Эффект: None None

Популяция: cerebral FURIN-deficient mice

Other 4 weeks
Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell …
Dose: 50, 100, or 200 mg/kg/day или: phosphatidylserine 50 mg/kg/day (positive control) Outcome: cognitive performance in scopolamine-induced memory impairment Эффект: None None

Популяция: male Sprague-Dawley rats with scopolamine-induced memory impairment

In Vitro
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.
Dose: None или: None Outcome: Age-dependent brain lipid changes Эффект: None None

Популяция: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)

Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d или: None Outcome: Cognitive decline in AD Эффект: None None

Популяция: Alzheimer's disease patients

Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice или: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Эффект: None None

Популяция: HFD-induced obese male C57BL/6 mice

Other
Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.
Dose: None или: None Outcome: Cognitive function Эффект: None None

Популяция: Mouse model

Key Statistics

16

Исследования

1100

Участники

Positive

B

Оценка

Referenced Papers

Journal of proteome … 2025 8 цитирований
The Senior care … 2021 2 цитирований
Frontiers in psychology 2018 13 цитирований
Nutrition (Burbank, Los … 2015 149 цитирований
Current treatment options … 2011 6 цитирований
Sports medicine (Auckland, … 2006 42 цитирований
Nutritional neuroscience 2002 46 цитирований
Alternative medicine review … 1999 112 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
100 mg/day
cognitivesupport:
100-300 mg/day

Верхний предел: Well-tolerated up to 600 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Negative --
50, 100, or 200 mg/kg/day 4 weeks Positive --
None -- Mixed --
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d -- Mixed --
50 mg/kg lycopene in mice -- Positive --
None -- Positive --
1 μg/mL -- Positive --
None 72 weeks Positive --

Лучшее время приёма: With meals for better absorption

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Mild gastrointestinal discomfort
  • Insomnia at high doses
  • Rare allergic reactions (soy-derived forms)

Известные взаимодействия

  • Anticholinergic medications (may reduce PS effectiveness)
  • Blood thinners (theoretical interaction)
  • Cholinesterase inhibitors (additive cholinergic effects)

Допустимый верхний уровень потребления: Well-tolerated up to 600 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Phosphatidylserine help with Age-Related Cognitive Decline?
Based on 16 studies with 1,100 participants, there is moderate evidence from clinical studies that Phosphatidylserine may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Phosphatidylserine?
Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 1,100 total participants. The overall direction of effect is positive.

Related Evidence

Phosphatidylserine для других состояний

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