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Taurine para Oxidative Stress & Neuroinflammation

C

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

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Conclusão

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

Key Study Findings

Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None vs: None Outcome: None Efeito: None None

População: narrative review of taurine neuroprotective actions in Alzheimer's disease

Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None vs: untreated 3xTg-AD mice Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism) Efeito: None None

População: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice

Controlled Clinical Trial 6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day vs: ROFA exposure without taurine Outcome: Multi-organ oxidative stress and neuroinflammation Efeito: None None

População: Male Wistar rats with intranasal ROFA exposure

Other n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None vs: Rotenone-induced PD model controls Outcome: Neuroprotection in rotenone-induced PD mice Efeito: None None

População: Rotenone-induced Parkinson's disease mice (10 groups)

Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None vs: HSV-1 infected cells/mice without taurine Outcome: HSV-1 infection and viral encephalitis severity Efeito: None None

População: HSV-1 viral encephalitis in vitro and mouse model

Other 4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks vs: Vehicle control in 5XFAD mice Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation Efeito: None None

População: 5XFAD AD mice and patient-derived cerebral organoids

Key Statistics

6

Estudos

300

Participantes

Positive

C

Nota

Referenced Papers

Psychoneuroendocrinology 2025 1 citações
NPJ Parkinson's disease 2024 57 citações
Alcohol (Fayetteville, N.Y.) 2015 122 citações
Frontiers in bioscience … 2015 62 citações
British journal of … 2014 111 citações

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
500-2,000 mg/day
cognitivesupport:
1,000-3,000 mg/day

Limite superior: 3,000 mg/day (EFSA safety assessment)

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive --
None -- Positive --
400 mg/kg/day 6 weeks Mixed --
None -- Positive 70
None -- Positive --
1000 mg/kg oral for 4 weeks 4 weeks Positive --
None -- Mixed --
None -- Mixed --

Melhor horário: With or without food; may be calming if taken evening

Safety & Side Effects

Efeitos Colaterais Relatados

  • Generally very well-tolerated
  • Mild gastrointestinal discomfort (rare)
  • Drowsiness at high doses

Interações Conhecidas

  • Antihypertensive drugs (additive blood pressure lowering)
  • Antiepileptic drugs (may enhance GABA effects)

Ingestão máxima tolerável: 3,000 mg/day (EFSA safety assessment)

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.