Omega-3 Fatty Acids (DHA/EPA) 用于 Cerebrovascular Health

Q: Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?

Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).

Q: How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

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结论

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs: None Outcome: None 效果: None None

研究人群: narrative review of ashwagandha clinical trials and basic research (1994-present)

Other 10 weeks

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of …

Dose: None vs: Untreated APP/PS1 mice Outcome: Cognitive performance in behavioral tests 效果: None None

研究人群: APP/PS1 transgenic Alzheimer's disease mouse model

Review

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines.

Dose: None vs: None Outcome: ASD symptom management 效果: None None

研究人群: Children with autism spectrum disorder

Cohort Study n=215624

Neuroticism, omega-3 fatty acids, and risk of incident dementia.

Dose: None vs: None Outcome: Incident all-cause dementia 效果: None <0.05 (Bonferroni)

研究人群: Dementia-free UK Biobank participants aged 40-69

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo 效果: None None

Other 26 weeks

Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk.

Dose: EPA 180mg + DHA 120mg vs: Simulated disease population baseline Outcome: Lipid biomarker changes (in silico model) 效果: 14.7% TG reduction, 22.38% HDL increase None

研究人群: Simulated CVD disease population (in silico study)

Key Statistics

研究数量

2000

受试者

↑

Positive

等级

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 次引用

Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. Review

Frontiers in nutrition 2025 7 次引用

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease. Other

Phytomedicine : international … 2025 6 次引用

Coenzyme Q10 and Cognition: A Review. Review

Nutrients 2025 2 次引用

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. Review

Alternative therapies in … 2025

Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk. Other

Scientific reports 2025

Neuroticism, omega-3 fatty acids, and risk of incident dementia. Other

Journal of affective … 2025

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. Review

Degenerative neurological and … 2024 66 次引用

[Not Available]. Review

Acta pharmaceutica Sinica. … 2024 33 次引用

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 次引用

Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy. Other

Biomedicines 2024 3 次引用

[Pharmacotherapies for insomnia]. Other

La Revue du … 2024

Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides. Review

International journal of … 2023 23 次引用

trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis. Other

Research (Washington, D.C.) 2022 38 次引用

Glucosinolates and Omega-3 Fatty Acids from Mustard Seeds: Phytochemistry and Pharmacology. Review

Plants (Basel, Switzerland) 2022 26 次引用

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 次引用

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. Other

Journal of cellular … 2022 15 次引用

Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging. Meta-Analysis

NeuroImage. Clinical 2022 14 次引用

A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm®) and Anthocyanins Exerts Beneficial Cardiovascular Effects. Other

Antioxidants (Basel, Switzerland) 2022 10 次引用

Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its … Other

Journal of ethnopharmacology 2022 8 次引用

Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. Other

BMJ open 2022 3 次引用

Comments on "dose-related meta-analysis for omega-3 fatty acids supplementation on major adverse cardiovascular events". Other

Clinical nutrition (Edinburgh, … 2022 1 次引用

Restless legs syndrome. Review

Nature reviews. Disease … 2021 163 次引用

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 次引用

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease. Other

The American journal … 2021 25 次引用

The Clinical Efficacy of Ginkgo biloba Leaf Preparation on Ischemic Stroke: A Systematic Review and Meta-Analysis. Review

Evidence-based complementary and … 2021 24 次引用

Fish consumption, long-chain omega-3 fatty acids intake and risk of stroke: An updated systematic review and meta-analysis. Meta-Analysis

Asia Pacific journal … 2021 16 次引用

Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats. Other

Journal of ethnopharmacology 2021 16 次引用

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 次引用

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. RCT

EBioMedicine 2020 107 次引用

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 次引用

Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity. RCT

The Journal of … 2020 33 次引用

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Systematic Review

Journal of integrative … 2020 33 次引用

The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … Other

Journal of clinical … 2020 17 次引用

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Review

South African medical … 2020 5 次引用

[Similarities and differences between Ginkgo biloba and Panax notoginseng in treatment of ischemic cerebrovascular disease]. Other

Zhongguo Zhong yao … 2020 3 次引用

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and … Review

Revue neurologique 2019 361 次引用

Multiple Health Benefits and Minimal Risks Associated with Vegetarian Diets. Review

Current nutrition reports 2019 68 次引用

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. RCT

Journal of psychiatric … 2019 46 次引用

Sleep Disorders in Wilson's Disease. Review

Current neurology and … 2019 11 次引用

Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. RCT

The journal of … 2018 24 次引用

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Other

Frontiers in aging … 2018 23 次引用

Brain imaging and networks in restless legs syndrome. Review

Sleep medicine 2017 95 次引用

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 次引用

Treatment of Sleep Dysfunction in Parkinson's Disease. Review

Current treatment options … 2017 56 次引用

Review of Safety and Efficacy of Sleep Medicines in Older Adults. Review

Clinical therapeutics 2016 328 次引用

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 次引用

Associations of dietary polychlorinated biphenyls and long-chain omega-3 fatty acids with stroke risk. Other

Environment international 2016 24 次引用

Concurrent Use of Low-Dose Aspirin and Omega-3 Fatty Acids and Risk of Upper Gastrointestinal Complications: A Cohort Study with Nested … Other

Basic & clinical … 2016 5 次引用

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Other

Molecular nutrition & … 2015 18 次引用

The Beyond Ageing Project Phase 2--a double-blind, selective prevention, randomised, placebo-controlled trial of omega-3 fatty acids and sertraline in an … RCT

Trials 2015 17 次引用

Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease. Other

Neurobiology of aging 2014 73 次引用

Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited. RCT

PloS one 2014 22 次引用

[The effects of Omega-3 fatty acids in clinical medicine]. Review

Praxis 2014 1 次引用

[Atrial fibrillation after coronary artery bypass surgery: possibilities of prevention]. Review

Srpski arhiv za … 2012 3 次引用

Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. Review

Journal of clinical … 2011 396 次引用

Alternative drug therapies for dementia. Other

Journal of psychosocial … 2011 26 次引用

OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted … RCT

Circulation 2010 593 次引用

Can nutrients prevent or delay onset of Alzheimer's disease? Review

Journal of Alzheimer's … 2010 110 次引用

Normal cognitive decline or dementia? Other

The Practitioner 2010

The potential role of nutritional components in the management of Alzheimer's Disease. Review

European journal of … 2008 49 次引用

Therapeutic options for sleep-maintenance and sleep-onset insomnia. Review

Pharmacotherapy 2007 117 次引用

Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. Review

Brain research reviews 2007 102 次引用

The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Other

Anesthesia and analgesia 2004 127 次引用

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Rural and remote … 2004 14 次引用

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The Cochrane database … 2003 263 次引用

Pharmacologic treatments of dementia. Review

The Medical clinics … 2002 59 次引用

Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Review

Life sciences 2000 41 次引用

Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens. Other

Poultry science 1995 16 次引用

Dietary omega-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries. Other

Stroke 1992 25 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 1,000-2,000 mg combined DHA/EPA per day
cognitivesupport:: 1,000-1,700 mg/day (optimal dose-response curve)

上限： 3,000 mg/day combined DHA/EPA (FDA GRAS)

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	--
None	10 weeks	Positive	--
None	--	Positive	--
None	--	Positive	215624
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
EPA 180mg + DHA 120mg	26 weeks	Positive	--
None	--	Mixed	--
None	--	Mixed	--

最佳服用时间： With meals containing fat for better absorption

Safety & Side Effects

已报告的副作用

⚠ Fishy aftertaste or burping
⚠ Mild gastrointestinal discomfort
⚠ Potential increased bleeding time at very high doses
⚠ May lower blood pressure slightly

已知相互作用

● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (may reduce omega-3 absorption)

可耐受最高摄入量： 3,000 mg/day combined DHA/EPA (FDA GRAS)

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?

Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).

How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

其他成分用于 Cerebrovascular Health

Ginkgo biloba B Resveratrol C

Omega-3 Fatty Acids (DHA/EPA) 用于其他健康状况

Age-Related Cognitive Decline A Mild Cognitive Impairment (MCI) B Depression-Related Cognitive Dysfunction B Attention & Focus Difficulties C

快速结论

Evidence Strength72%

High confidence

研究分析

RCT (8)Meta (3)Other (1)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于 Cerebrovascular Health

了解更多

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