What is the recommended dosage for Gotu Kola?

General: 500-1,000 mg/day standardized extract; Cognitive Support: 750 mg/day

What are the side effects of Gotu Kola?

Potential side effects include: Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness, Rare: liver toxicity at very high doses.

Gotu kola (Centella asiatica) is an herb used in traditional Ayurvedic and Chinese medicine. It contains triterpene compounds, including asiaticoside and madecassoside, that have been studied for their potential to support memory, reduce anxiety, and promote neural regeneration.

What dosage of Gotu Kola has been used in studies?

Studies have used 250 mg to 1,000 mg of standardized extract daily, or 1 g to 4 g of the dried herb. Cognitive studies have most commonly used 250 mg to 500 mg of extract standardized for triterpene content. Consult your healthcare provider for guidance.

What are the potential side effects of Gotu Kola?

Gotu kola may cause headache, stomach upset, nausea, and drowsiness. Rare cases of liver toxicity have been reported with prolonged use at high doses. It may interact with sedative and hepatotoxic medications. Consult your healthcare provider before use.

Gotu Kola

herb

Also known as: Centella asiatica, Indian Pennywort, Mandukparni

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About

Gotu Kola is a traditional Ayurvedic brain tonic whose triterpene saponins promote nerve growth and dendritic arborization. Emerging evidence supports its role in enhancing collagen synthesis in cerebral blood vessels and modulating GABAergic activity.

How It Works

Triterpene saponins (asiaticoside, madecassoside) promote nerve growth and dendritic arborization; enhances collagen synthesis in cerebral blood vessels; modulates GABAergic activity.

Evidence For Conditions

Condition	Grade	Studies	Participants
Age-Related Cognitive Decline	D	4	200	View →

Side Effects

Skin irritation (topical)
Headache
Gastrointestinal discomfort
Drowsiness
Rare: liver toxicity at very high doses

Drug & Supplement Interactions

Hepatotoxic drugs (additive liver stress)
Sedative medications (additive CNS depression)
Cholesterol-lowering drugs (theoretical interaction)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Ashwagandha Bacopa monnieri Ginkgo biloba Panax Ginseng Rhodiola rosea

Quick Facts

Dosage: General: 500-1,000 mg/day standardized extract; Cognitive_Support: 750 mg/day
Forms: capsule tablet powder tea
Natural Sources: Centella asiatica plant (tropical wetlands of Asia)
Upper Limit: Not established; hepatotoxicity reported rarely at very high doses
Best Time: With meals

Evidence Summary

Age-Related Cognitive Decline D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.