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Taurine Oxidative Stress & Neuroinflammation

C

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

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C

結論

Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.

Key Study Findings

Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None vs: None Outcome: None 効果: None None

対象集団: narrative review of taurine neuroprotective actions in Alzheimer's disease

Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None vs: untreated 3xTg-AD mice Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism) 効果: None None

対象集団: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice

Controlled Clinical Trial 6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day vs: ROFA exposure without taurine Outcome: Multi-organ oxidative stress and neuroinflammation 効果: None None

対象集団: Male Wistar rats with intranasal ROFA exposure

Other n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None vs: Rotenone-induced PD model controls Outcome: Neuroprotection in rotenone-induced PD mice 効果: None None

対象集団: Rotenone-induced Parkinson's disease mice (10 groups)

Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None vs: HSV-1 infected cells/mice without taurine Outcome: HSV-1 infection and viral encephalitis severity 効果: None None

対象集団: HSV-1 viral encephalitis in vitro and mouse model

Other 4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks vs: Vehicle control in 5XFAD mice Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation 効果: None None

対象集団: 5XFAD AD mice and patient-derived cerebral organoids

Key Statistics

6

研究数

300

参加者数

Positive

C

グレード

Referenced Papers

Psychoneuroendocrinology 2025 1 件の引用
NPJ Parkinson's disease 2024 57 件の引用
Alcohol (Fayetteville, N.Y.) 2015 122 件の引用
Frontiers in bioscience … 2015 62 件の引用
British journal of … 2014 111 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:
500-2,000 mg/day
cognitivesupport:
1,000-3,000 mg/day

上限量: 3,000 mg/day (EFSA safety assessment)

研究で検討された用量

用量 期間 効果 N
None -- Positive --
None -- Positive --
400 mg/kg/day 6 weeks Mixed --
None -- Positive 70
None -- Positive --
1000 mg/kg oral for 4 weeks 4 weeks Positive --
None -- Mixed --
None -- Mixed --

推奨摂取タイミング: With or without food; may be calming if taken evening

Safety & Side Effects

報告されている副作用

  • Generally very well-tolerated
  • Mild gastrointestinal discomfort (rare)
  • Drowsiness at high doses

既知の相互作用

  • Antihypertensive drugs (additive blood pressure lowering)
  • Antiepileptic drugs (may enhance GABA effects)

耐容上限摂取量: 3,000 mg/day (EFSA safety assessment)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。